Amoxicillin and amoxicillin-clavulanic acid resistance in veterinary medicine - the situation in Europe: a review

Belmar-Liberato, R.; González-Canga, Aránzazu; Tamame-Martin, P.; Escribano-Salazar, M.

doi:10.17221/3293-vetmed

Cited by 19 publications

(13 citation statements)

References 35 publications

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“…One isolate was classified as a multidrug resistant strain (SCHWARZ et al, 2010), based on its resistance to amoxicillin/ clavulanic acid, trimethoprim/sulfamethoxazole, and florfenicol. Identification of a multidrug resistant strain is concerning as trimethoprim/ sulfamethoxazole and florfenicol are commonly used to treat diarrhea in foals and calves (KUANG et al, 2015) and amoxicillin/clavulanic acid is widely used in both veterinary and human medicine (BELMAR-LIBERATO, 2011;OTEO et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial susceptibility and molecular characterization of Salmonella serovar Ndolo isolated from outbreaks in cattle and horses

et al. 2018

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The present study aimed to describe and characterize, for the first time, two outbreaks of salmonellosis caused by Salmonella Ndolo in foals and calves in Brazil and compare the isolated strains with S. Ndolo previously identified in asymptomatic reptiles. The affected calves and foals presented fever, lethargy, and profuse diarrhea. Isolated strains were subjected to antimicrobial susceptibility testing, characterized according to virulence genes, and fingerprinted by ERIC-PCR. Salmonella Ndolo was identified in fecal samples from two foals and four calves. One isolate from a calf was resistant to amoxicillin/clavulanic acid, trimethoprim/sulfamethoxazole, and florfenicol. Strains from two other calves were resistant to oxytetracycline. All virulence genes tested were present in the isolates, and two major clusters of closely related strains were identified by ERIC-PCR, each per outbreak. This is the first report of Salmonella Ndolo infection in domestic and symptomatic animals. Previously, this serovar had been identified only in human infections. The presence of relevant virulence genes in all Salmonella Ndolo isolates and the detection of antimicrobial multi-resistant strains highlighted the importance of monitoring serovars associated with salmonellosis in domestic animals. RESUMO:O objetivo do presente estudo foi descrever e caracterizar, pela primeira vez, dois surtos de salmonelose causados por Salmonella Ndolo em potros e bezerros do Brasil e comparar esses isolados com Salmonella Ndolo previamente identificada em répteis assintomáticos. Os animais infectados apresentaram febre, letargia e diarreia profusa. Os isolados foram submetidos a testes de susceptibilidade a antimicrobianos e foram caracterizados conforme a presença de genes de virulência e diversidade genética, utilizando-se o ERIC-PCR. Salmonella Ndolo foi identificado em amostras fecais de dois potros e quatro bezerros. Um isolado de bezerro foi resistente a amoxicilina/ácido clavulanico, trimethoprima/sulfametoxazol e florfenicol. Estirpes de dois outros bezerros foram resistentes a oxitetraciclina. Todos os genes de virulência testados foram identificados nos isolados e dois grandes grupos de estirpes geneticamente relacionadas foram identificados pelo ERIC-PCR, um para cada surto. Esse é o primeiro relato de Salmonella Ndolo em animais domésticos e sintomáticos. Previamente, esse sorovar foi identificado apenas em infecções humanas. A presença de fatores de virulência relevantes em todos os isolados e a detecção de estirpes multirresistentes a antimicrobianos destaca a importância do monitoramento de sorovares associados a salmonelose em animais domésticos.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial susceptibility and molecular characterization of Salmonella serovar Ndolo isolated from outbreaks in cattle and horses

et al. 2018

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“…A high frequency of resistance to aminopenicillins has been reported among clinical E. coli isolates of different origin worldwide [ 32 ]. Our results for amoxicillin confirmed this observation.…”

Section: Discussionmentioning

confidence: 99%

Multidrug Resistance in Escherichia coli Strains Isolated from Infections in Dogs and Cats in Poland (2007–2013)

Rzewuska

Czopowicz

Kizerwetter-Świda

et al. 2015

The Scientific World Journal

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The antimicrobial susceptibility of Escherichia coli isolates associated with various types of infections in dogs and cats was determined. The studied isolates were most frequently susceptible to fluoroquinolones and the extended-spectrum cephalosporins (ESCs), antimicrobials commonly used in treatment of infections in companion animals. However, an increase in the percentage of strains resistant to β-lactam antibiotics including ESCs was noted between January 2007 and December 2013. The frequency of multidrug-resistant (MDR) E. coli isolation (66.8% of isolates) is alarming. Moreover, the statistically significant increase of the percentage of MDR isolates was observed during the study period. No difference in the prevalence of multidrug resistance was found between bacteria causing intestinal and extraintestinal infections and between canine and feline isolates. Nonhemolytic E. coli isolates were MDR more often than hemolytic ones. Our study showed the companion animals in Poland as an important reservoir of MDR bacteria. These results indicate that continuous monitoring of canine and feline E. coli antimicrobial susceptibility is required. Furthermore, introduction and application of recommendations for appropriate use of antimicrobials in small animal practice should be essential to minimize the emergence of multidrug resistance among E. coli in companion animals.

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“…Methanol is used as control for the assay. [6] 50 µL of freshly prepared cell suspension (required organism) was inoculated into freshly prepared and sterilized nutrient agar medium by maintaining optimum temperature and transferred to sterile petri dishes and allowed them to solidify. The dishes or plates were placed on a smooth surface to ensure that the layers of medium are uniform in thickness.…”

Section: Preparation Of Drug Sample Dilutionsmentioning

confidence: 99%

Comparison of Antimicrobial Activity and Mic of Branded and Generic Forms of Amoxicillin

Vasavi¹,

B²,

Mallika³

et al. 2017

IJAPB

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The present work is about to determine the efficacy of different Branded and generic pharmaceuticals (antimicrobials). Branded formulations are at high cost, so that the poor can't afford to buy them. Therefore the generic drugs of various pharmaceutical companies are sold at low cost are checked for their therapeutic efficacy by comparing with that of branded for their efficacy (antimicrobial activity). Different branded and generic formulations of Amoxicillin were selected and their efficacy was tested by using cup plate method and minimum inhibitory concentration of drug that is effective towards microorganism.

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Amoxicillin and amoxicillin-clavulanic acid resistance in veterinary medicine - the situation in Europe: a review

Cited by 19 publications

References 35 publications

Antimicrobial susceptibility and molecular characterization of Salmonella serovar Ndolo isolated from outbreaks in cattle and horses

Antimicrobial susceptibility and molecular characterization of Salmonella serovar Ndolo isolated from outbreaks in cattle and horses

Multidrug Resistance in Escherichia coli Strains Isolated from Infections in Dogs and Cats in Poland (2007–2013)

Comparison of Antimicrobial Activity and Mic of Branded and Generic Forms of Amoxicillin

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