Amoxicillin/Metronidazole Dose Impact as an Adjunctive Therapy for stage II - III grade C Periodontitis (Aggressive Periodontitis) at 3- And 6-Month Follow-Ups: a Systematic Review and Meta-Analysis

Abstract

Objectives: This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II -III grade C periodontitis (aggressive periodontitis) after current follow-up. Material and Methods: An electronic search of the literature was performed in three main databases for relevant articles published until 31 th of December 2021. According to the PRISMA statement, the extracted data from selected articles were pooled. The weighted mean difference (MD) and 95% confidence interval (CI) of clinical attachment level (CAL) gain and probing depth (PD) reduction at 3 and 6 months of follow-up were calculated. The heterogeneity of the data was evaluated by the I 2 test. Results: The results of six randomized clinical trials revealed significant improvement of clinical parameters in moderate and severe pockets. Prescription of 400 to 500 mg metronidazole caused significant CAL gain changes just in moderate pockets (MD = 1.82; 95% CI = 1.11 to 2.53; P < 0.05). Conclusions: Amoxicillin/metronidazole has positive short-term effects as an adjunct to scaling and root planning for treatment of stage II -III grade C periodontitis. Higher doses of metronidazole (400 to 500 mg) are required for optimal efficacy regarding clinical attachment level gain.

Efficacy of Isolated and Combined Application of Topical Metronidazole and Chlorhexidine in the Treatment of Periodontal Inflammation a Randomized Controlled Trial

“…Finding of this research is somehow similar found in previous study, done in Dental College and Research Institute, of India where metronidazole gel, and chlorhexidine gel were used in periodontal problems (20) , another trial was also taken as a reference for this research which demonstrated the effectiveness of usage of metronidazole gel, on overgrowth of gingiva due to cyclosporine (21) However, this study shows clinically and statically significant reductions of periodontal inflammation in all three treatment groups from baseline to 12 th week.…”

Predicting the Physician’s Specialty Using a Medical Prescription Database

“…In this case, the combination of amoxicillin-metronidazole has the 21st rank among the 25 most frequently selected variables, which has the highest importance in making an accurate prediction. This is despite the fact that the recent systematic review and meta-analysis research about simultaneously amoxicillin/metronidazole usage in periodontitis treatment has shown positive shortterm effects [26]. In addition, considering the extracted results showed that acetaminophen existed in several 2combs.…”

Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy

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