Amoxycillin Trihydrate Floating-Bioadhesive Drug Delivery System for Eradication of Helicobacter pylori: Preparation, In Vitro and Ex Vivo Evaluation

Dudhipala, Narendar; Narala, Arjun

doi:10.4172/jbb.1000280

Cited by 11 publications

(12 citation statements)

References 17 publications

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“…The capsule was kept in a basket; the weight of the capsule was taken at a different time interval (W 2 ). Percent hydration (Swelling index) was calculated 22 from the following formula:…”

Section: D) Water Uptake Studies (Determination Of Swelling Index)mentioning

confidence: 99%

Untitled

2019

IJPSR

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Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and evaluate gastro-retentive diltiazem hydrochloride modified pulisincap floating capsules. Diltiazem hydrochloride modified pulsincap floating capsules were formulated by filling the drug-polymer and diluents mixture in cross-linked hard gelatin capsules. Total of 15 formulations was developed and evaluated for pre capsule filling and post capsule filling parameters. Before development of formulation with different polymers, the cross-linked hard gelatin capsules were filled with only pure drug to carry out the diffusion studies of the drug through the cross-linked hard gelatin capsules among the developed, formulation containing carbopol 934p, i.e. F12 formulation was considered to be optimized based on its in-vitro drug release data and have shown the invitro drug release of 97.64 ± 3.45% at the end of 12 th h, in-vitro drug release data were fitted into different kinetic models, optimized formulation has shown the zero order drug release with a mechanism of non-fickian diffusion, radiographic studies confirmed that optimized formulation with BaSO 4 administered to the healthy volunteer with food have shown more gastric residence time than that of the optimized formulation with BaSO 4 administered to the healthy volunteer in fasting condition. INTRODUCTION: Diltiazem HCl is an active pharmaceutical compound that absorbs maximum specifically from the upper part of the gastrointestinal tract (GI) and poorly absorbed from QUICK RESPONSE CODE

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“…The capsule was kept in a basket; the weight of the capsule was taken at a different time interval (W 2 ). Percent hydration (Swelling index) was calculated 22 from the following formula:…”

Section: D) Water Uptake Studies (Determination Of Swelling Index)mentioning

confidence: 99%

Untitled

2019

IJPSR

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“…Bu sistemlerle yapılan bir çalışmada, amoksisilin trihidratlı biyoadeziv yüzen tabletler H. pylori tedavisi için geliştirilmiştir. 7 Seçilen optimum formüllü biyoadeziv tabletler, H. pylori'yi yok etmede başarılı bulunmuştur.…”

Section: Mi̇dede Kaliş Süresi̇ni̇ Etki̇leyen Faktörlerunclassified

Pharmaceutical Approach to the Floating/Gastroretentive Systems in Stomach

Özsoy¹,

Özçelik²

2018

J Lit Pharm Sci

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Ö ÖZ ZE ET T Uzatılmış oral etkin madde salım sistemleri; doz sıklığındaki azalma, plazma konsantrasyon seviyesindeki dalgalanmaların azalması ve artan hasta uyuncu nedeni ile oldukça ilgi çeken sistemlerdir. Bu sistemler içinde yer alan yüzen sistemler eğer kısa gastrik kalış süresi ve beklenmeyen gastrik boşalma zamanı sorunları başarıyla halledilebilir ise son derece umut verici yaklaşımlardır. Bu sistemlerle, üst gastrointestinal bölgede emilimleri kısıtlı ve biyoyararlanımı düşük etkin maddeler için emilimlerinin artırılmasına bağlı olarak; etkinliklerinin artırılması, bazı durumlarda klinik dezavantajlarının dengelenebilmesi, mide ve duodenal ülserlerin tedavisinde yararlı stratejiler oluşturabilme ve bölgeye spesifik etkin madde uygulanabilme gibi faydalar sağlanabilmektedir. Bu tip ilaç şekillerinin geliştirilmesi sırasında, ilaç şeklinin istenilen ve yeterli periyotta midede kalabilmesinin zor olması, terapötik çeşitlilik içinde etkin maddenin emiliminin tamamlanamaması gibi zorluklarla karşılaşılmakla beraber, gelişime açık olmalarına engel olamamıştır. Bu sistemler, dansite kontrolü sağlanarak gastrik içerikte kalabilmelerinden dolayı uzatılmış zaman periyodunda gastrik boşalma zamanından etkilenmemektedirler. Buna bağlı olarak, gastrik geçiş zamanı arttığından plazma etkin madde konsantrasyonundaki dalgalanmaların daha iyi kontrol edilebilmesi sağlanmaktadır. Dolayısıyla yüzen ilaç şekillerine, biyoadeziv ilaç şekillerine, raft (sal) formundaki sistemlere, şişen ve genişleyen midede kalabilen ilaç şekillerine artan bir ilgi bulunmaktadır. Bu tarz sistemler, midede yüzerek uzun süre kalmayı ve etkin madde salımını uzatmayla beraber plazma etkin madde seviyesindeki dalgalanmaların daha iyi kontrol edilmesine olanak verebilmektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Gastrointestinal kanal; gecikmeli hazırlıklar; ilaç dağıtım sistemleri A AB BS S T TR RA AC CT T Extended drug delivery systems are increasingly attracted due to reduction in dose frequency, decreasing of fluctuations in plasma concentration level and raising patient compliance. Floating systems are the part of in these systems and extremely hopeful approaches if low gastric residence time and unexpectable gastric emptying time problems are able to solve. Especially for the drugs which have the low absorption in upper gastrointestine and low bioavailability are increased their effectiveness by increased absorption, balancing of clinical disadvantages in some stuations, be able to create useful strategies for the treatment of gastritis and duodenal ulcers and it is possible to provide benefits about drug application to the specific region. During the development of such dosage forms, it is difficult to remain in the desired and adequate period, and with difficulties such as the inability to complete absorption of the drug in therapeutic diversity but their development did not prevent from being open for improvement. Because these systems can maintain in gastric content by providing density control, so they are not affecte...

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“…The liquid enters the particles through pores and bind to large molecule, breaking the hydrogen bond and resulting in the swelling of particle. [20] The extent of swelling can be measured in terms of % weight gain by the tablet. The floating bioadhesive tablets of simvastatin made up of polymeric matrices build a gel layer around the tablet core when they come in contact with water.…”

Section: Swelling Studymentioning

confidence: 99%

“…After each interval, the tablet was removed from beaker and weighed again up to 12 h. The SI study was performed in triplicate and it calculated using following formula. [20] Swelling index (S.I) = {(wt-wo)/wo}×100…”

Section: Si Studymentioning

confidence: 99%

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Untitled

Nawaj¹

2017

AJP

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Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.

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Amoxycillin Trihydrate Floating-Bioadhesive Drug Delivery System for Eradication of Helicobacter pylori: Preparation, In Vitro and Ex Vivo Evaluation

Cited by 11 publications

References 17 publications

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Pharmaceutical Approach to the Floating/Gastroretentive Systems in Stomach

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