Objective: The aim & objectives of this research work was to explore applicability of our previously synthesized sulfoxy amine chitosan in design, development and evaluation of transdermal drug delivery of Gliclazide. Methods: To determine the interaction between excipients used and to find out the nature of drug in the formulation, Fourier transforms infra-red spectroscopy (FTIR) and Differential Scanning Colorimetry (DSC) studies were performed. Gliclazide containing transdermal patch were formulated with help of Sulfoxy Amine Chitosan, HPMC, Penetration enhancer Dimethyl Sulfoxide and Glycerine by using solvent casting method.9 formulations prepared by using 32 full factorial designs the effect of formulation variable was studied on % Moisture Content, Folding endurance, % Cumulative drug release at 12 hrs.Formulated transdermal patches were evaluated for various parameters. Results: FTIR & DSC suggest study no drug & polymers interaction .All the prepared transdermal patches were found to be faint yellow in colored, flexible, uniform, smooth, and transparent. The weight of the transdermal patches for different type of formulations ranged between 12.00 ± 0.6 mg & 14.2 ± 0.52 mg. The thickness of the patches varied from 0.171 ± 0.0035 mm to 0.182 ± 0.0026 mm. The moisture content & water vapour transmission rate in the patches ranged from 2.33 to 4.55% & from 0.002246 to 0.003597 mg.cm/cm2 24hrs.XRD diffractogram revealed  pure Gliclazide exhibited characteristic high-intensity diffraction peaks & optimized formulation showed  three peaks in 2θ= 20.6 28.7 and 38.95 with very weak intensities. Optimized batch F7 showed maximum drug release 98.41%. The folding endurance was lies in between 301 and 359. Optimization study was successfully conducted using 32 factorial designs. Conclusion: We concluded that transdermal patches Gliclazide of was successfully formulated with synthesized Sulfoxy Amine Chitosan & evaluated.

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Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.