AMP-Activated Protein Kinase Signalling

Neumann, Dietbert; Viollet, Benoı̂t

doi:10.3390/ijms20030766

Cited by 7 publications

(11 citation statements)

References 27 publications

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“…Phosphorylated AMPK is 100-fold more active than the native protein. Actually, apart from the allosteric regulation, AMPK is involved in a kinase cascade (8,12,17). It has been shown that various growth factors and hormones can promote AMPK activation through its phosphorylation.…”

Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

“…It has been shown that various growth factors and hormones can promote AMPK activation through its phosphorylation. Reportedly, apart from LKB1, calcium/calmodulin-dependent protein kinase (CAMKK), transforming growth factor-beta-activated kinase (TAK1) and ataxia telangiectasia mutated protein may function as AMPK kinases (9,12).…”

Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

“…On the other hand, it may also act as a metabolic survival factor in distinct tumor types (26). Furthermore, AMPK has been shown to affect the signalling pathway mediated by the cAMP-dependent protein kinase (PKA) activation and cAMP-responsive element-binding protein (CREB) phosphorylation in different cell types (12,27). In hepatocytes, biguanides suppress CREB phosphorylation by decreasing the production of cAMP and their effect is mediated by AMPK (28,29).…”

Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

“…Metformin is believed to activate AMPK by affecting cell metabolism and causing a decrease of the ATP:AMP ratio with the outcome of allosteric binding of AMP to the AMPK regulatory subunit γ, which makes AMPK a better substrate for its upstream kinase LKB1 (12). Actually, the evidence that the indirect activation of AMPK in cultured pituitary gonadotroph cells by a drug can significantly alter gonadotropin release and the sensitivity to GnRH suggests also to consider AMPK as an intracellular target of hormonal signals mediating information about the systemic energy status at the anterior pituitary cells.…”

Section: Gonadotroph Cell Functionmentioning

confidence: 99%

“…Apart from being a direct sensor of energy store within cells and a mediator of endogenous signals, including hormones and inflammatory factors, AMPK is also regulated by drugs currently approved for the treatment of different pathologies, newly developed compounds in drug discovery and natural compounds (i.e. resveratrol) from foods (12).…”

Section: Introductionmentioning

confidence: 99%

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How treatments with endocrine and metabolic drugs influence pituitary cell function

Tulipano

2020

Endocrine Connections

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A variety of endocrine and metabolic signals regulate pituitary cell function acting through the hypothalamus-pituitary neuroendocrine axes or directly at the pituitary level. The underlying intracellular transduction mechanisms in pituitary cells are still debated. AMP-activated protein kinase (AMPK) functions as a cellular sensor of low energy stores in all mammalian cells and promotes adaptive changes in response to calorie restriction. It is also regarded as a target for therapy of proliferative disorders. Various hormones and drugs can promote tissue-specific activation or inhibition of AMPK by enhancing or inhibiting AMPK phosphorylation, respectively. This review explores the preclinical studies published in the last decade that investigate the role of AMP-activated protein kinase in the intracellular transduction pathways downstream of endocrine and metabolic signals or drugs affecting pituitary cell function, and its role as a target for drug therapy of pituitary proliferative disorders. The effects of the hypoglycemic agent metformin, which is an indirect AMPK activator, are discussed. The multiple effects of metformin on cell metabolism and cell signalling and ultimately on cell function may be either dependent or independent of AMPK. The in vitro effects of metformin may also help highlighting differences in metabolic requirements between pituitary adenomatous cells and normal cells.

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Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

Section: Amp-activated Protein Kinase (Ampk) Regulation and Activitymentioning

confidence: 99%

Section: Gonadotroph Cell Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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How treatments with endocrine and metabolic drugs influence pituitary cell function

Tulipano

2020

Endocrine Connections

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Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways

Sehati

Ahmadi

Farivar

et al. 2021

Neuroscience Letters

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WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

Zhang

et al. 2023

Commun Biol

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AMPK plays significant roles in the modulation of metabolic reprogramming and viral infection. However, the detailed mechanism by which AMPK affects viral infection is unclear. The present study aims to determine how AMPK influences white spot syndrome virus (WSSV) infection in shrimp (Marsupenaeus japonicus). Here, we find that AMPK expression and phosphorylation are significantly upregulated in WSSV-infected shrimp. WSSV replication decreases remarkably after knockdown of Ampkα and the shrimp survival rate of AMPK-inhibitor injection shrimp increases significantly, suggesting that AMPK is beneficial for WSSV proliferation. Mechanistically, WSSV infection increases intracellular Ca2+ level, and activates CaMKK, which result in AMPK phosphorylation and partial nuclear translocation. AMPK directly activates mTORC2-AKT signaling pathway to phosphorylate key enzymes of glycolysis in the cytosol and promotes expression of Hif1α to mediate transcription of key glycolytic enzyme genes, both of which lead to increased glycolysis to provide energy for WSSV proliferation. Our findings reveal a novel mechanism by which WSSV exploits the host CaMKK-AMPK-mTORC2 pathway for its proliferation, and suggest that AMPK might be a target for WSSV control in shrimp aquaculture.

show abstract

AMP-Activated Protein Kinase Signalling

Abstract: AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotic cells and organisms [...]

Cited by 7 publications

References 27 publications

How treatments with endocrine and metabolic drugs influence pituitary cell function

How treatments with endocrine and metabolic drugs influence pituitary cell function

Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

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