AMP challenge induces a decrease in FE<sub>NO</sub> in asthmatic subjects modulated by nedocromil

Bruce, C.; Zhao, Delong; Yates, Deborah H; Thomas, Paul S.

doi:10.1111/j.1365-2362.2006.01736.x

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Earlier studies have found that bronchoconstriction with histamine, hypertonic saline, exercise, or adenosine 5Ј-monophosphate can cause a decrease in FE NO by 20 -40%; that the fall in FE NO is correlated with a fall in FEV 1 ; and that the FE NO will subsequently increase after treatment with albuterol. [23][24][25][26][27] The effect of airway caliber might partially explain the large variability in FE NO measurements at various time points. The relationship between FEV 1 and FE NO must be considered in future investigations of NO in the patient with acute asthma.…”

Section: Discussionmentioning

confidence: 98%

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Baptist

Shah

Wang

et al. 2008

allergy asthma proc

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The time required for fractional excretion of nitric oxide (FE(NO)) measurements to acutely change after systemic corticosteroids is unknown, limiting the usefulness of this biomarker in hospital treatment and discharge decisions. The purpose of this study was to follow FE(NO) measurements of hospitalized adult patients with asthma receiving therapy and to correlate FE(NO) with forced expiratory volume in 1 second percent predicted (FEV(1)%). Ten acute asthmatic patients who required hospitalization were recruited and treated with standard therapy. FE(NO) measurements were performed at presentation to the emergency department (baseline), as well as 1, 4, 6, 8, 12, and 24 hours after the initiation of therapy. FEV(1)% was measured at baseline, 1, 6, 12, and 24 hours. Subjects also were called 3 days after discharge to assess if symptoms had improved. The baseline FE(NO) was 57.5 parts per billion (ppb). There was no significant change over the first 8 hours. At 12 hours, there was an increase to 96.5 ppb (p = 0.01). Compared with baseline, all 10 subjects showed an increase at the 12-hour time point, with an average increase of 52%. The correlation between change in FE(NO) and change in FEV(1)% approached significance (p = 0.089). Subjects who improved after discharge had a greater percent increase in FE(NO) than those who did not (p = 0.043). FE(NO) measurements increase in hospitalized asthmatic patients receiving therapy. This augmentation appears to be associated with improvements in FEV(1). Asthmatic patients who show a greater increase in FE(NO) may have better outcomes after discharge.

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Section: Discussionmentioning

confidence: 98%

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Baptist

Shah

Wang

et al. 2008

allergy asthma proc

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“…Changes correlate significantly with the percentage fall in FEV 1, suggesting that the decrease in F e NO may be a function of change in airway calibre 89 . However, one study has shown that the NOS2 inhibitor aminoguanidine inhibited the reduction of F e NO with AMP challenge, suggesting a possible role of NOS2 in the AMP‐induced decrease of F e NO 90 . Allergen challenge in atopic asthmatic subjects results in an increase in F e NO in asthma 91,92 associated with an increase in inflammatory cytokines 92 .…”

Section: Fraction Of No In the Exhaled Breath (Feno)mentioning

confidence: 99%

“…89 However, one study has shown that the NOS2 inhibitor aminoguanidine inhibited the reduction of FeNO with AMP challenge, suggesting a possible role of NOS2 in the AMP-induced decrease of FeNO. 90 Allergen challenge in atopic asthmatic subjects results in an increase in FeNO in asthma 91,92 associated with an increase in inflammatory cytokines. 92 The pre-allergen challenge levels of FeNO correlated significantly with the magnitude of the late fall in FEV1.…”

Section: Factors Affecting Feno Measurementsmentioning

confidence: 99%

Fractional exhaled nitric oxide in asthma: an update

et al. 2009

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Nedocromil sodium for chronic asthma in children

Sridhar

McKean

2006

Cochrane Database of Systematic Reviews

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A limited number of small studies have shown that nedocromil is of benefit in improving lung function and some measures of symptoms, but the evidence with regard to the primary outcome of the review was conflicting. Two long-term trials did not show consistent effects on lung function outcomes, whereas several small short-term trials have shown benefit in these outcomes. Differing severities at baseline may explain this difference with milder participants experiencing less benefit, although the discrepancy between study findings may also reflect publication bias. Nedocromil sodium is associated with a very good safety profile with no significant short term or long- term adverse side effects. Although nedocromil may have advantages over inhaled corticosteroids in terms of side effects, there is a need for head to head trials of nedocromil and inhaled corticosteroids to establish whether asthma control is similar, especially in mild asthma. It is not yet clear where nedocromil should sit in relation to other therapies in the treatment of asthma in children.

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AMP challenge induces a decrease in FE_NO in asthmatic subjects modulated by nedocromil

Cited by 4 publications

References 37 publications

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Fractional exhaled nitric oxide in asthma: an update

Nedocromil sodium for chronic asthma in children

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AMP challenge induces a decrease in FENO in asthmatic subjects modulated by nedocromil

Cited by 4 publications

References 37 publications

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Fractional exhaled nitric oxide in asthma: an update

Nedocromil sodium for chronic asthma in children

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Product

Resources

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AMP challenge induces a decrease in FE_NO in asthmatic subjects modulated by nedocromil