&amp;lt;i&amp;gt;Morinda citrifolia&amp;lt;/i&amp;gt; (Noni) Fruit Juice Inhibits SARS-CoV-2 Spike Protein Binding of Angiotensin-Converting Enzyme 2 (ACE2)

West, Brett J.; Deng, Shixin

doi:10.4236/jbm.2021.911005

Cited by 4 publications

(1 citation statement)

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“…The administration of deacetylasperulosidic acid lowered hepatocyte steatosis and adipocyte hypertrophy, suggesting its usefulness for the management of obesity (Esakkimuthu et al, 2019). Moreover, deacetylasperulosidic acid had a moderated activity for preventing the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2 for infection to host cells (West and Deng, 2021).…”

Section: Pharmacological Activity Of Deacetylasperulosidic Acidmentioning

confidence: 99%

Monotropein: A comprehensive review of biosynthesis, physicochemical properties, pharmacokinetics, and pharmacology

Lai²,

Peng

et al. 2023

Front. Pharmacol.

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Monotropein, a principal natural compound in iridoid glycosides extracted from Morindae officinalis radix, has potent pharmacological activities. To understand and utilize monotropein, we systematically summarized the studies on monotropein, including its biosynthetic pathway, physicochemical properties, pharmacokinetics, and pharmacology. Interestingly, we found that the multiple bioactivities of monotropein, such as anti-osteoporosis, anti-inflammation, anti-oxidation, anti-nociception, and hepatic or renal protection, are closely associated with its capability of downregulating the nuclear factor-κB signaling pathway, inhibiting the mitogen-activated protein kinase signaling pathway, attenuating the activation of nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway, and regulating the mammalian target of rapamycin/autophagy signaling pathway. However, the clinically therapeutic effects and the potential problems need to be addressed. This review highlights the current research progress on monotropein, which provides a reference for further investigation of monotropein.

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Section: Pharmacological Activity Of Deacetylasperulosidic Acidmentioning

confidence: 99%