Amperometric detection of thiopurines in blood plasma with a cobalt-phthalocyanine chemically modified electrode after liquid chromatography

Modified multiwall carbon nanotubes paste electrode as a sensor for simultaneous determination of 6-thioguanine and folic acid using ferrocenedicarboxylic acid as a mediator

“…MCNTs have been introduced as electrocatalysts [38,39] and CNTs modified electrodes have been reported to give super-performance in the study of a number of biological species, including cytochrome c [40], uric acid [41], NADH [42], quercetin [43], and epinephrine [44]. However, few publications are available regarding electrochemical determination of 6-TG in real samples using chemically modified electrodes such as dsDNA fabricated on 2-aminoethanethiol self-assembled monolayer film modified gold electrode [10], cobalt phthalocyanine-containing carbon paste electrodes [45], and/or p-aminophenol modified carbon paste electrode [11].…”

Reactivity trends of Fe phthalocyanines confined on graphite electrodes in terms of donor–acceptor intermolecular hardness: Linear versus volcano correlations

“…On the other hand, the study of the reactivity of chemically modified electrodes containing immobilized MN4 macrocyclic complexes with specific activities for a given reaction is important because of the great variety of applications of these systems in electrocatalysis in sensors [8][9][10][11][12][13][14]. Metal phthalocyanines (MPc's) when confined on electrode surfaces are very active and versatile catalysts for a great variety of ET reactions [11].…”

Application of the iodine–azide postcolumn reaction in RP‐HPLC for the determination of thioguanine in urine

“…The detection of thioguanine in various matrixes: serum [5], plasma [6 -13], red blood cell [14 -20], erythrocyte [9 -11], urine [8 -9, 11 -13, 21], capillary blood [22], lymphoblasts [23], lymphocyte [24], chines hamster ovary cells [25], L5178Y murine lympoma cell [26,27], human lung tissue [7], and lymphoblastic leukemia cell line MOLT-4 [28] has been conducted with the use of several methods including chromatographic methods with UV [5 -14, 16 -23, 25, 26, 29], fluorimetric [15,16,18,25,27,28], and electrochemical detection techniques [30]. However, most of the methods require the inevitable and tedious procedures of sample preparation for the precipitation of protein [6, 10, 12, 13, 19, 21 -23], SPE [11], liquidliquid exctration [4,17,18,20], or derivatization step [18,20,24,25,28].…”