Amperometric detection of tumor suppressor protein p53 via pencil graphite electrode for fast cancer diagnosis

Deepa, .; Nohwal, Bhawna; Chaudhary, Reeti; Pundir, C.S.

doi:10.1016/j.ab.2021.114528

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…By harnessing electrochemical currents, amperometric biosensors can provide real-time measurements of neurotransmitter concentrations, thus making them invaluable tools for understanding neural processes and diagnosing neurological disorders [ 47 ]. Amperometric biosensors for neurotransmitter detection consist of three main components, namely, electrodes, biorecognition elements, and working solutions [ 48 , 49 ]. The biorecognition element is typically an enzyme that is selective to the neurotransmitter of interest.…”

Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous system, and they also perform roles in realizing the function and maintaining the state of each organ in the body. The dysregulation of neurotransmitters can cause neurological disorders. This highlights the significance of precise neurotransmitter monitoring to allow early diagnosis and treatment. This review provides a complete multidisciplinary examination of electrochemical biosensors integrating nanomaterials and nanotechnologies in order to achieve the accurate detection and monitoring of neurotransmitters. We introduce extensively researched neurotransmitters and their respective functions in biological beings. Subsequently, electrochemical biosensors are classified based on methodologies employed for direct detection, encompassing the recently documented cell-based electrochemical monitoring systems. These methods involve the detection of neurotransmitters in neuronal cells in vitro, the identification of neurotransmitters emitted by stem cells, and the in vivo monitoring of neurotransmitters. The incorporation of nanomaterials and nanotechnologies into electrochemical biosensors has the potential to assist in the timely detection and management of neurological disorders. This study provides significant insights for researchers and clinicians regarding precise neurotransmitter monitoring and its implications regarding numerous biological applications.

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Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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“…The immunosensor had a high sensitivity of 60.65 µA/Log (pg/mL)-cm 2 with other advantages such as good specificity and selectivity for p53 and fast detection time of 90-150 s as well as being applicable in clinical settings. Very recently, Nohwal and colleagues [75] fabricated a simple amperometric immunosensor for p53 detection as shown in Figure 8. A Pencil graphite electrode (PGE) was first dipped into piranha solution and then p53 antibodies were immobilized onto the electrode surface and was used to capture p53 antigen in the sample.…”

Section: Label-free Ec Immunosensors For P53 Detectionmentioning

confidence: 99%

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Ekwujuru

Olatunde

Klink

et al. 2023

Sensors

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Photoelectrochemical (PEC) sensing is an emerging technological innovation for monitoring small substances/molecules in biological or non–biological systems. In particular, there has been a surge of interest in developing PEC devices for determining molecules of clinical significance. This is especially the case for molecules that are markers for serious and deadly medical conditions. The increased interest in PEC sensors to monitor such biomarkers can be attributed to the many apparent advantages of the PEC system, including an enhanced measurable signal, high potential for miniaturization, rapid testing, and low cost, amongst others. The growing number of published research reports on the subject calls for a comprehensive review of the various findings. This article is a review of studies on electrochemical (EC) and PEC sensors for ovarian cancer biomarkers in the last seven years (2016–2022). EC sensors were included because PEC is an improved EC; and a comparison of both systems has, expectedly, been carried out in many studies. Specific attention was given to the different markers of ovarian cancer and the EC/PEC sensing platforms developed for their detection/quantification. Relevant articles were sourced from the following databases: Scopus, PubMed Central, Web of Science, Science Direct, Academic Search Complete, EBSCO, CORE, Directory of open Access Journals (DOAJ), Public Library of Science (PLOS), BioMed Central (BMC), Semantic Scholar, Research Gate, SciELO, Wiley Online Library, Elsevier and SpringerLink.

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Nanostructured poly(thiophene acetic acid)/Au/poly(methylene blue) interface for electrochemical immunosensing of p53 protein

2023

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Amperometric detection of tumor suppressor protein p53 via pencil graphite electrode for fast cancer diagnosis

Cited by 8 publications

References 20 publications

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Nanostructured poly(thiophene acetic acid)/Au/poly(methylene blue) interface for electrochemical immunosensing of p53 protein

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