Amphetamine differentially modifies the expression of monoaminergic and GABAergic synaptic boutons and processes in lateral habenula, dorsal and ventral hippocampal formation

Yin, Hsiang‐Shu; Tien, Ta–Chang; Li, Li-Tzu; Yang, Yueying; Lai, Chuan-Ching

doi:10.1016/j.neuro.2011.10.001

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…The whole-mount immunofluorescence method had been employed to investigate the development of nervous system in mollusc larvae [10,17,32,35,36]. In the present study, to further understand the development of catecholaminergic nervous system, the CfDDC and CfDBH immunoreactive cells were detected simultaneously by the whole-mount immunofluorescence method in scallop larvae.…”

Section: Discussionmentioning

confidence: 83%

The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri

Zhou

Wang

Shi

et al. 2012

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 83%

The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri

Zhou

Wang

Shi

et al. 2012

Fish & Shellfish Immunology

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“…GABAergic alterations by psychostimulant intake may also contribute to the altered LHb neuronal excitability. A single dose of amphetamine induces a drastic reduction in parvalbumin levels of GABAergic afferents to the LHb, suggesting altered calcium levels and potentially altered release probability in these GABAergic terminals (Yin et al, 2012). There are indications that the effect of cocaine is not homogeneous across the LHb.…”

Section: The Role Of the Lhb In The Acute Effects Of Psychostimulantsmentioning

confidence: 99%

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

Lecca

Meye

Mameli

2014

Eur J of Neuroscience

173

124

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The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems. Over the past few years a renewed interest in the LHb has emerged due to studies highlighting its central role in encoding rewarding and aversive aspects of stimuli. Moreover, an increasing number of functional as well as behavioral indications provide substantial evidence supporting a role of LHb in neuropsychiatric diseases, including mood disorders and drug addiction. Cellular and synaptic adaptations in the LHb may therefore represent a critical phenomenon in the etiology of these diseases. In the current review we describe the anatomical and functional connections allowing the LHb to control the dopamine and serotonin systems, as well as possible roles of these connections in motivated behaviors and neuropsychiatric disorders. Finally, we discuss how drug exposure and stressful conditions alter the cellular physiology of the LHb, highlighting a role for the LHb in the context of drug addiction and depression.

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“…Prolonged cocaine withdrawal (21 days) increased binding of a radiolabeled benzodiazepine (which binds to GABA A Rs) in the whole LHb, whereas acute withdrawal from this treatment slightly decreased binding (Keys and Ellison, 1999). Furthermore, withdrawal from amphetamine yielded bidirectional differences in GABAergic markers in the LHb, depending on drug concentration (Yin et al, 2012). These findings indicate that drastic adaptations occur in GABAergic innervation of the LHb upon psychostimulant exposure.…”

Section: Synaptic Transmission In the Lateral Habenula (Lhb)mentioning

confidence: 99%

Synaptic and cellular profile of neurons in the lateral habenula

Meye

Lecca

Valentinova

et al. 2013

Front. Hum. Neurosci.

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The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecting to the midbrain, may represent an important cellular correlate for neuropsychiatric disorders like depression and drug addiction. Despite the recent insights regarding the implications of the LHb in the context of reward and aversion, the exact nature of the synaptic and cellular players regulating LHb neuronal functions remains largely unknown. Here we focus on the synaptic and cellular physiology of LHb neurons. First, we discuss the properties of excitatory transmission and the implications of glutamate receptors for long-term synaptic plasticity; second, we review the features of GABAergic transmission onto LHb neurons; and finally, we describe the contribution that neuromodulators such as dopamine (DA) and serotonin may have for LHb neuronal physiology. We relate these findings to the role that the LHb can play in processing aversive and rewarding stimuli, both in health and disease states.

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Amphetamine differentially modifies the expression of monoaminergic and GABAergic synaptic boutons and processes in lateral habenula, dorsal and ventral hippocampal formation

Cited by 7 publications

References 42 publications

The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri

The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

Synaptic and cellular profile of neurons in the lateral habenula

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