Amphicrine Tumor of the Vulva

Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?

“…9 Analogous to this, amphicrine carcinoma represents a rare form of malignancy that is composed of neoplastic cells with dual exocrine and NE differentiation. These unique tumours are reported at various sites, [10][11][12][13][14][15][16][17][18][19][20][21][22] predominantly within the gastrointestinal tract. [10][11][12][13][14][15][16][17][18][19] Unlike mixed adenoneuroendocrine carcinoma (MANEC) (also known as mixed neuroendocrine-nonneuroendocrine neoplasm 23 ), amphicrine carcinomas comprise a single neoplastic population rather than an admixture of morphologically distinct NE and non-NE components.…”

Amphicrine (mixed adenoneuroendocrine carcinoma) of the duodenum and coexistent metastatic well differentiated neuroendocrine tumour

“…The term "amphicrine" was advocated by Ratzenhofer in 1977 for cells which synchronously displayed exocrine and endocrine differentiation. 1 Amphicrine cells have been divided into two subgroups 2,3 : cells which have the endocrine and exocrine component separated in the cytoplasm (apical mucus granules and basal neuroendocrine granules) and, cells which have both components Amphicrine carcinomas are extremely rare, however they have been described in various organs, such as skin, 3 sinonasal cavities, 5 larynx, 6 lung, 7,8 gastrointestinal tract, 9e12 pancreas, 13 thyroid, 14,15 breast, 16 middle ear, 17 uterine cervix, 18 vulva 19 and prostate. 20 Mandoky reported 16 cases of amphicrine carcinomas from various organs including stomach, duodenum, ileum and cecum.…”