Amphiphilic multiblock copolymers of PLLA, PEO and PPO blocks: Synthesis, properties and cell affinity

Loiola, Lívia M.D.; Más, Bruna Antunes; Duek, Eliana A. R.; Felisberti, Maria I.

doi:10.1016/j.eurpolymj.2015.03.034

Cited by 15 publications

(15 citation statements)

References 43 publications

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“…The dynamic mechanical properties associated to PLLA‐ b ‐PEO‐ b ‐PLLA block copolymer relaxations have been previously described elsewhere . The DMA results imply that the PLLA‐ b ‐PEO‐ b ‐PLLA copolymer and both nanocomposites are multiphase systems.…”

Section: Resultsmentioning

confidence: 61%

“…The DMA results imply that the PLLA‐ b ‐PEO‐ b ‐PLLA copolymer and both nanocomposites are multiphase systems. E ′ decreases by one order of magnitude in the temperature range of the PEO glass transition, indicating that the copolymer presents a morphology of a PEO phase dispersed in a PLLA matrix …”

Section: Resultsmentioning

confidence: 99%

“…PLLA‐ b ‐PEO‐ b ‐PLLA amphiphilic triblock copolymers present a flexible and hydrophilic PEO middle block, and hard and hydrophobic PLLA end blocks. The non‐cytotoxic character of PLLA‐ b ‐PEO‐ b ‐PLLA was previously demonstrated thorough PicoGreen ® assays, indicating that these copolymers are biocompatible candidates for tissue engineering applications . No individual polymer, however, can meet all the requirements for the design of temporary devices.…”

Section: Introductionmentioning

confidence: 99%

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Thermal and mechanical properties of nanocomposites based on a PLLA‐b‐PEO‐b‐PLLA triblock copolymer and nanohydroxyapatite

Loiola

Fasce

Silva

et al. 2016

J of Applied Polymer Sci

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Composites which combine biocompatible polymers and hydroxyapatite are unique materials with regards to their mechanical properties and bioactivity in the development of temporary bone‐fixation devices. Nanocomposites based on a biocompatible and amphiphilic triblock copolymer of poly(l‐lactide) (PLLA) and poly(ethylene oxide) (PEO) —PLLA‐b‐PEO‐b‐PLLA— and neat (nHAp) or PEO‐modified (nHAp@PEO) hydroxyapatite nanoparticles were prepared by dispersion in benzene solutions, followed by freeze‐drying and injection moulding processes. The morphology of the copolymers of a PEO block dispersed throughout a PLLA matrix was not changed with addition of the nanofillers. The nHAp particles were spherical and, after modification, the nHAp@PEO nanoparticles were partially agglomerated. In the nanocomposites, these particles characteristics remained unchanged, and the nHAp particles and nHAp@PEO agglomerates were uniformly dispersed through the copolymer matrix. These particles acted as nucleating agents, with nHAp@PEO being more efficient. The incorporation of nHAp increased both the reduced elastic modulus (∼22%) and the indentation hardness (∼15%) in comparison to the copolymer matrix, as determined by nanoindentation tests, while nHAp@PEO addition resulted in lower increments of these mechanical parameters. The incorporation of untreated nHAp was, therefore, more beneficial with regards to the mechanical properties, since the amphiphilic PLLA‐b‐PEO‐b‐PLLA matrix was already efficient for nHAp nanoparticles dispersion. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44187.

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Section: Resultsmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermal and mechanical properties of nanocomposites based on a PLLA‐b‐PEO‐b‐PLLA triblock copolymer and nanohydroxyapatite

Loiola

Fasce

Silva

et al. 2016

J of Applied Polymer Sci

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“…The reduction in the number of segregated domains when increasing the PLLA content suggests that these domains are richer in PEG and PTMC. The segregation of the PEG‐rich phases in PLLA–PEG block copolymers was also verified using the AFM technique by Loiola et al and Lucke et al …”

Section: Resultsmentioning

confidence: 68%

Effect of diisocyanates and chain extenders on the physicochemical properties and morphology of multicomponent segmented polyurethanes based on poly(l‐lactide), poly(ethylene glycol) and poly(trimethylene carbonate)

Trinca

Felisberti

2015

Polymer International

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Multicomponent segmented polyurethanes (SPUs) based on poly(ethylene glycol), poly(l‐lactide) and poly(trimethylene carbonate) as macrodiols, 2,4‐toluene diisocyanate (2,4‐TDI) or 1,6‐hexane diisocyanate (HDI) as diisocyanate, and 1,4‐butanediol (BDO) or 2,2‐bis(hydroxymethyl)propionic acid (DMPA) as chain extenders were synthesized. The molecular, thermal, dynamic mechanical and morphological features of this set of uncrosslinked polyurethanes are characterized using 1H NMR, gel permeation chromatography, differential scanning calorimetry, dynamic mechanical thermal analysis (DMTA) and atomic force microscopy techniques. The lower reaction rate of HDI in comparison with 2,4‐TDI allows for better control of the SPU compositions, so that the intrinsic properties of each block can be better combined and modulated. HDI‐based SPUs are semi‐crystalline, while those based on 2,4‐TDI are amorphous, affecting the mechanical properties of these polyurethanes. All SPUs are heterogeneous, presenting morphologies of a disperse phase in a matrix which varies with the macrodiol ratios as well as with the nature of the diisocyanate and chain extender (a finer dispersion of the disperse phase is observed for SPUs of HDI and BDO). DMTA results indicate that the phases are complex mixtures of the different blocks with at least one rich in PLLA. The PEG content is shown to be the most important factor influencing the water sorption capability, while the incorporation of hindering carboxylic acid groups by the use of DMPA allows the water uptake of SPUs to be controlled by the solution pH. All SPUs show a significant loss of molar mass in hydrolytic degradation experiments and, in general, the PLLA‐rich SPUs are more susceptible to degradation. © 2015 Society of Chemical Industry

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“…Copolymers were synthesized by ring‐opening polymerization (ROP) in anhydrous toluene solutions ( m copolymer : V toluene = 1:10) under N 2 atmosphere, as previously described . Briefly, appropriate amounts of PEO 8 or PEO 3 –PPO 2 –PEO 3 macroinitiators and Sn(Oct) 2 catalyst ( n catalyst : n macroinitiator = 2:1) were solubilized in toluene and heated to reflux (bp.…”

Section: Methodsmentioning

confidence: 99%

Amphiphilic polylactide‐poly(ethylene oxide)‐poly(propylene oxide) block copolymers: Self‐assembly behavior and cell affinity

Loiola

Farias

Portugal

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Polylactide (PLA) is a biodegradable polyester recognized for its potential use as a biomedical material. Poly(ethylene oxide) (PEO) and copolymers based on PEO and poly(propylene oxide) (PPO) are biocompatible polyethers widely applied in the biomedical field, particularly as macromolecular nonionic surfactants. In this work, PLA blocks were attached to the PEO and to the PEO and PPO‐based triblock copolymer PEO–PPO–PEO, through ring‐opening polymerization of racemic lactide (rac‐LA) to obtain the amphiphilic triblock PLA–PEO–PLA and pentablock PLA–PEO–PPO–PEO–PLA copolymers containing hydrophilic/hydrophobic blocks with variable block mass ratios. The copolymers were evaluated for chemical composition, molar mass, and thermal properties, and they were used to prepare self‐assemble aggregates in water from tetrahydrofuran polymer solutions. The combination of scattering light experiments and microscopy techniques revealed the spherical morphology of the aggregates with diameters around 180–200 nm, which comprises a hydrophobic PLA core and a hydrophilic polyether shell. The aggregates are nontoxic to human cervical cancer cell line — HeLa cells, as determined by MTS assay, and the aggregates are potential candidates to be applied in the encapsulation of hydrophobic compounds. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2203–2213

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Amphiphilic multiblock copolymers of PLLA, PEO and PPO blocks: Synthesis, properties and cell affinity

Cited by 15 publications

References 43 publications

Thermal and mechanical properties of nanocomposites based on a PLLA‐b‐PEO‐b‐PLLA triblock copolymer and nanohydroxyapatite

Thermal and mechanical properties of nanocomposites based on a PLLA‐b‐PEO‐b‐PLLA triblock copolymer and nanohydroxyapatite

Effect of diisocyanates and chain extenders on the physicochemical properties and morphology of multicomponent segmented polyurethanes based on poly(l‐lactide), poly(ethylene glycol) and poly(trimethylene carbonate)

Amphiphilic polylactide‐poly(ethylene oxide)‐poly(propylene oxide) block copolymers: Self‐assembly behavior and cell affinity

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