Amphotericin B and Caspofungin Resistance in Candida glabrata Isolates Recovered from a Critically Ill Patient

Krogh-Madsen, Mikkel; Arendrup, Maiken Cavling; Heslet, Lars; Knudsen, Jenny Dahl

doi:10.1086/500939

Cited by 191 publications

(130 citation statements)

References 19 publications

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“…However, in many clinical laboratories agar diffusion method with application of Etest (AB Biodisk, Solna, Sweden) is also used as a quick and reliable method of testing susceptibility [19][20]. Comparison of the in vitro susceptibility to antimycotics of strains examined in this study by Etest and ATB Fungus system, with data presented by other authors, led to following conclusions:…”

Section: Discussionsupporting

confidence: 56%

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Susceptibility of Candida spp. clinical isolates to antimycotics and disinfectants

et al. 2010

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Abstract:The incidence of candidiasis among immunocompromised patients and emergence of antimycotics resistant strains has increased significantly. The aims of this study were: to examine the in vitro activity of antimycotics and biocides against Candida clinical isolates; to detect cross-resistance of fungi to these preparations and to estimate whether disinfectants applied in hospital areas are active against clinical Candida isolates. In vitro susceptibility of 102 Candida isolates to eight antimycotics was examined by Etest and ATB Fungus. Sensitivity of these strains to four disinfectants and an antiseptic agent was tested according to EN 1275:2005. Amphotericin B, caspofungin and 5-fluorocytosine were the most effective antimycotics against all Candida isolates. Resistance to itraconazole and fluconazole was observed among C. krusei and C. glabrata. The MICs (Minimal Inhibitory Concentrations) for ketoconazole, voriconazole and posaconazole against Candida albicans ranged: 0.003 ->32 µg/ml and one strain was resistant to three agents tested. All analysed Candida strains were sensitive to biocides containing either chlorine, aldehyde, alcohol mixtures, glucoprotamin or chlorhexidine gluconate with isopropanol. Sensitivity to these agents was observed at concentrations lower than those concentrations recommended by manufacturers to achieve proper biocidal activity to those preparations. Our data suggest that these disinfectants can be effectively applied in clinical wards to prevent nosocomial Candida infections.

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Section: Discussionsupporting

confidence: 56%

“…to antimycotics, disinfectants and an antiseptic agent used to treat patients, disinfect surfaces, medical devices and also used as hygienic hand rubs. (9), drain swabs (20) and other samples (11).…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of Candida spp. clinical isolates to antimycotics and disinfectants

et al. 2010

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“… Echinocandin resistant C. albicans, C. glabrata, C. tropicalis and C. krusei have been reported [247][248][249][250].  C. parapsilosis, C. orthopsilosis, C. metapsilosis and C. guilliermondii are known to possess intrinsic resistance to echinocandins [251].…”

Section: Echinocandins Eg Caspofungin Micafungin and Anidulafunginmentioning

confidence: 99%

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Bandara

Matsubara

Samaranayake

2016

Expert Review of Anti-infective Therapy

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“…Of the 20 patients studied, 40% had cancer, and when compared to controls, risk factors were mucositis, longer stay in the ICU, longer periods of hyperalimentation, mechanical ventilation, urinary catheter, and use of broad-spectrum antibiotics. Similarly, one case report documented a C. glabrata isolate with a specific profile of resistance in a critically ill patient, that was resistant to both amphotericin B and caspofungin [17]. In a retrospective analysis of two ICU patient cohorts, Rocco et al [18] analyzed the effect of fluconazole administration on Candida sensitivity.…”

Section: Prophylactic Antifungal Treatment In the Icumentioning

confidence: 99%

Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment

et al. 2008

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Background: Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). Objective and methods: To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and an European expert panel discussion. Results and conclusions: Empiric and directed treatment for invasive candidiasis are predicated on the hemodynamic status of the patient. Unstable patients may benefit from broad-spectrum antifungal agents, which can be narrowed once the patient has stabilized and the identity of the infecting species is established. In stable patients, a more classical approach using fluconazole may be satisfactory provided that the patient is not colonized Intensive Care Med

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Amphotericin B and Caspofungin Resistance in Candida glabrata Isolates Recovered from a Critically Ill Patient

Cited by 191 publications

References 19 publications

Susceptibility of Candida spp. clinical isolates to antimycotics and disinfectants

Susceptibility of Candida spp. clinical isolates to antimycotics and disinfectants

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment

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