2018
DOI: 10.1159/000489154
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AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

Abstract: Background/Aims: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized that PT may confer protection against myocardia… Show more

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Cited by 47 publications
(34 citation statements)
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“…In random skin flaps, post-ischemic reperfusion induces oxidative stress and apoptosis, leading to tissue damage ( Kosuru et al, 2018 ). In the early stages of oxidative stress, ROS react with cell membrane lipids and proteins, triggering peroxidation and destruction of cells ( Anet et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…In random skin flaps, post-ischemic reperfusion induces oxidative stress and apoptosis, leading to tissue damage ( Kosuru et al, 2018 ). In the early stages of oxidative stress, ROS react with cell membrane lipids and proteins, triggering peroxidation and destruction of cells ( Anet et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…33 Cell viability was measured using the CCK-8 kit (Solarbio). 33 Cell viability was measured using the CCK-8 kit (Solarbio).…”
Section: Determination Of Cellular Injurymentioning
confidence: 99%
“…Oxidative Medicine and Cellular Longevity cells. Nevertheless, current studies shall stimulate further studies to be conducted both in vivo and ex vivo to confirm and to explore the underlying mechanisms, such as why cardiomyocyte hypoxia/reoxygenation leads to increased AMPK activation with concomitant reductions in STAT3 activation but a further increase in AMPK activation induced by HPo and/or by APN-increased STAT3 activation [41].…”
mentioning
confidence: 93%