Diabetes is a global menace, and its severity results
in various
disorders including cardiovascular, retinopathy, neuropathy, and nephropathy.
Recently, diabetic conditions are diagnosed through the level of glycated
hemoglobin. The level of glycated hemoglobin is determined with enzymatic
methodology. Although the system is sensitive, it has various restrictions
such as long processing times, expensive equipment required for testing,
and complex steps involved in sample preparation. These limitations
are a hindrance to faster results. The limitations of the developed
methods can be eliminated through biosensors. In this work, an electrochemical
platform was fabricated that facilitates the identification of glycated
hemoglobin protein in diabetic patients. The working electrode on
the integrated circuit was modified with molecularly imprinted polymer
decorated with tungsten disulfide nanoparticles to enhance its analytical
properties. The analytical properties of the biosensor were studied
using electrochemical techniques. The obtained detection limit of
the nanoelectronic sensor was 0.01 pM. The calculated sensitivity
of the biosensor was observed to be 0.27 μA/pM. Also, the sensor
promises to operate in a dynamic working concentration range and provide
instant results.