Amplified luminescence quenching effect upon binding of nitrogen doped carbon nanodots to transition metal ions

Abstract

The ‘J- or H-emissive aggregate model’ proposed for carbon nanodots is validated by monitoring their fluorescence quenching in different solutions with varying hydrogen bonding strengths.

Erlotinib Conjugated Nitrogen Doped Carbon Nanodots for Targeted Fluorescence Imaging of Human Pancreatic Cancer Cells

“…Most importantly, a breakthrough in the emissive aggregate model for CDs occurred when Kumbhakar's group reported experimental findings demonstrating the self‐assembly nature of certain CDs in polar solvents into typical H‐aggregates . Our research group gets motivated by these results and we validated this ‘H‐aggregate model’ by observing solvent effects on optical properties and transition metal ion‐induced amplified luminescence quenching of typical CDs . Our results recognised J‐, H‐ and JH‐ aggregate like behaviour of CDs in polar solvents.…”

“…[14,24] Our research group gets motivated by these results and we validated this 'H-aggregate model' by observing solvent effects on optical properties and transition metal ioninduced amplified luminescence quenching of typical CDs. [25,26] Our results recognised J-, H-and JH-aggregate like behaviour of CDs in polar solvents. In continuation of such previous results, it is visualised that interaction of hydrophilic CD with cationic organic drugs and proteins can be used to interrogate the aggregate structure of CDs.…”

“…Our results recognised J‐, H‐ and JH‐ aggregate like behaviour of CDs in polar solvents. In continuation of such previous results, it is visualised that interaction of hydrophilic CD with cationic organic drugs and proteins can be used to interrogate the aggregate structure of CDs …”

“…In continuation of such previous results, it is visualised that interaction of hydrophilic CD with cationic organic drugs and proteins can be used to interrogate the aggregate structure of CDs. [25][26][27] Herein, we designed fluorescent EGFR targeted nitrogen doped carbon nanodots (NCD) by a surface coating of NCD with erlotinib. Furthermore, targeted NCD is used to label EGFR overexpressed human pancreatic cancer cells (PANC-1).…”

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

“…Another ion that can quench the PL of CNDs is Fe 3+ [42,[114][115][116][117][118][119][120], but this is highly susceptible to interference by other metal ions. To improve the efficiency of Fe 3+ biosensors, Qian et al found that L-lysine recovers the PL quenched by Fe 3+ .…”