Amplitude changes of auditory potentials evoked at cochlear nucleus during acoustic habituation

Worden, Frederic G.; Marsh, James T.

doi:10.1016/0013-4694(63)90176-7

Cited by 61 publications

(12 citation statements)

References 7 publications

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“…The latter finding is consistent with earlier studies of primary sensory evoked responses (e. g. Hernandez-Peon et aI., 1956), but the fact that responses of all moda lities decrease during novel stimulation of any modality does not support the earlie r hypothesis that inputs of irrelevant modalities are suppre ssed, at 154 least for association responses. The absence of association response habituation to repeated click stimulation differs from earlier reports of evoked response habituation in the primary auditory system (Hernande z-Peon et aI., 1957) but is consistent with the negative findings of more recent studies (Worden & Marsh, 1963).…”

Section: Dlsl~usslonsupporting

confidence: 90%

Dependence of evoked cortical association responses on behavioral variables

Shaw

Thompson

1964

Psychon Sci

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Evoked responses to auditory, visual and tactile stimulation were recorded from posterior association cortex in the normal waking cat. Association response amplitudes to all modalities of stimulation decreased during bodily activity and during novel stimulation of any modality. Association responses to repeated auditory stimulation did not habituate. ProblemAlthough there have been many investigations of primary sensory evoked responses in the normal waking cat, little information is available concerning nonspecific evoked responses recorded from "association" areas of the cortex with this preparation. Responses of the suprasylvian gyrus to tactile nerve stimulation have been reported to decrease during EEG arousal (AlbeFessard et aI., 1960). In the chloralosed cat there are four restricted cortical association response fo~i which respond in an equivalent fashion to all modalities of stimulation (Thompson et aI., 1963). This study was planned to investigate characteristics of posterior cortical association responses in the normal waking cat and their possible dependence upon behavioral variables. ~IethodA total of 50 bipolar electrodes recording across the cortex were implanted in the suprasylvian gyrus in 16 cats. Recording was such that upward deflections on the oscilloscope represented positivity at the surface electrode relative to the depth electrode. Animals were studied one week after implantation. Stimuli were an SO-db free-field click, shock to ipsilateral forepaw skin through implanted wire sutures, and light flash. Head position was monitored in all procedures .Two independent variables were studied: "behavioral state" and habituation. Two classes of behavioral state were defined, one by a simple rating scale of bodily activity and the other in terms of novel stimulus presentation, novel meaning any stimulus of" significance" to the animal which was not otherwise present in the experiment. Samples of 20 or more consecutive evoked responses to stimuli given once every 2 sec. were photographically superimposed for each condition of bodily activity, novel stimulus presentation and habituation testing. Habituation training was a click every 2 sec. for 70 hr. Control records for behavioral state, and all records for habituation, were taken when the animal was sitting or lying motionless with eyes open. Evoked association response amplitudes were normally distributed, permitting use of various statistical approximation methods (Dixon & Massey, 1957, pp. 272-275).

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Section: Dlsl~usslonsupporting

confidence: 90%

Dependence of evoked cortical association responses on behavioral variables

Shaw

Thompson

1964

Psychon Sci

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“…Contractions of middle-ear muscles have been implicated in some studies of auditory evoked response habituation (Guzman-Flores, Alcaraz, & Harmony, 1960;Hugelin, Dumont, & Paillas, 1960), but denied by other workers (Altman, 1960;Moushegan, Rupert, Marsh, & Galambos, 1961). Further discussion of methodological problems is given in the careful studies by Marsh et al (1962) and Worden and Marsh (1963). (See also the discussion by Deutsch, 1962.…”

Section: Sensory Evoked Potentialsmentioning

confidence: 98%

“…Worden and Marsh (1963) have emphasized the importance of controlling stimulus intensity, demonstrating statistically reliable changes in response, and conducting other necessary control procedures which were not always observed in the studies listed above. Experiments satisfying all these methodological criteria have not, for the most part, found any consistent or significant evidence of habituation of auditory evoked responses in the waking animal (Huttenlocher, 1960;Marsh, McCarthy, Sheatz, & Galambos, 1961;Sharpless & Jasper, 1956;Worden & Marsh, 1963). However Marsh and Worden (1964) have recently reported decreases in clickevoked response amplitudes from the auditory cortex when the EEG was desynchronized, even in the absence of any consistent response changes at the cochlear nucleus.…”

Section: Sensory Evoked Potentialsmentioning

confidence: 99%

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

Thompson¹,

Spencer²

1966

Psychological Review

2,393

1,633

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The recent habituation literature is reviewed with emphasis on neurophysiological studies. The hindlimb flexion reflex of the acute spinal cat is used as a model system for analysis of the neuronal mechanisms involved in habituation and sensitization (i.e., dishabituation). Habituation of this response is demonstrated to follow the same 9 parametric relations for stimulus and training variables characteristic of behavioral response habituation in the intact organism. Habituation and sensitization appear to be central neural processes and probably do not involve presynaptic or postsynaptic inhibition. It is suggested that they may result from the interaction of neural processes resembling "polysynaptic low-frequency depression," and "facilitatory afterdischarge." "Membrane desensitization" may play a role in long-lasting habituation.

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“…Careful studies by Worden and associates (see Worden and Marsh, 1963; Marsh, Worden, and Hicks, 1962) demonstrated that click evoked responses at the cochlear nucleus do not show habituation. Instead, amplitudes of responses at this first relay nucleus in the auditory system are rigidly controlled by the physical properties of the sound stimulus.…”

mentioning

confidence: 99%