Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

Song, Jeong Sup

doi:10.1016/j.biopha.2023.114647

Cited by 18 publications

(3 citation statements)

References 318 publications

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“…This has also been shown in women with PCOS 37 , but the exact mechanism is not fully understood. The amygdala is a region in the brain that regulates emotional memory, anxiety, and cognitive function 38 . Since insulin was positively associated with symptoms of anxiety and depression, we hypothesize that insulin resistance can have effects in the amygdala.…”

Section: Discussionmentioning

confidence: 99%

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome

Kataoka,

Olsson,

Lindgren

et al. 2024

Sci Rep

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is associated with an increased risk of anxiety and depression and with a lower health-related quality of life (HRQoL). PCOS is closely associated with obesity, which per se can lead to symptoms of anxiety and depression and lower HRQoL. The first-line treatment for PCOS is weight loss through lifestyle intervention, which has been shown to improve all symptoms of the syndrome. The aim of this study was to investigate symptoms of anxiety and depression and HRQoL in women with severe obesity (BMI ≥ 35) with and without PCOS, and to evaluate the effect of a one-year structured weight loss intervention. A total of 246 women with severe obesity (PCOS n = 63, non-PCOS n = 183) were included. The comprehensive psychopathological rating scale self-rating scale for affective symptoms (CPRS-S-A) and the short form-36 (SF-36) were used to assess symptoms of anxiety and depression and HRQoL. In total 72 women of the 246 women with severe obesity completed a one-year weight loss programme and were followed up and compared with baseline data. In women with severe obesity, there were no differences in symptoms of anxiety and depression and HRQoL between women with and without PCOS at baseline. Clinically relevant anxiety symptoms were present in 71.3% (PCOS) and 65.6% (non-PCOS), and depression symptoms were present in 56.4% (PCOS) and 52.2% (non-PCOS). Significant weight loss improved physical HRQoL in all women, but reduced symptoms of anxiety and depression only in women without PCOS. There were no differences when comparing the changes between the groups. Women with severe obesity are severely affected by symptoms of anxiety and depression, independent of PCOS. Weight loss improved symptoms of anxiety and depression in women without PCOS, but there were no differences between groups in change from baseline to follow-up.Trial registration number: Clinical trial.gov: NCT01319162, March 18, 2011. Date of registration and enrolment of the first subject September 2011.

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Section: Discussionmentioning

confidence: 99%

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome

Kataoka,

Olsson,

Lindgren

et al. 2024

Sci Rep

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show abstract

“…Song et al. found that the number of patients with cognitive decline due to metabolic imbalances has increased considerably ( Song, 2023 ). Mounting evidence suggests that metabolic regulation is necessary to prevent and treat neuropsychiatric disorders.…”

Section: Underlying Mechanisms Of a Muciniphila In...mentioning

confidence: 99%

“…Both human and animal studies have been utilized to explore the concurrence of neuropsychiatric disorders and metabolic diseases, revealing shared pathophysiological mechanisms, such as dyslipidemia (Yu et al, 2020), insulin resistance (Ma et al, 2022), neurovascular dysfunction (Xu et al, 2022), neuronal cell loss (Bharadwaj et al, 2017), and tubulin-associated unit (tau) phosphorylation (Freude et al, 2005). Song et al found that the number of patients with cognitive decline due to metabolic imbalances has increased considerably (Song, 2023). Mounting evidence suggests that metabolic regulation is necessary to prevent and treat neuropsychiatric disorders.…”

Section: Metabolic Regulationmentioning

confidence: 99%

Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Lei

Cheng

Gao³

et al. 2023

Front. Cell. Infect. Microbiol.

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An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila exhibits positive systemic effects on host health, mainly by improving immunological and metabolic functions, and it is therefore regarded as a promising potential probiotic. Recent clinical and preclinical studies have shown that A. muciniphila plays a vital role in a variety of neuropsychiatric disorders by influencing the host brain through the microbiota-gut-brain axis (MGBA). Numerous studies observed that A. muciniphila and its metabolic substances can effectively improve the symptoms of neuropsychiatric disorders by restoring the gut microbiota, reestablishing the integrity of the gut mucosal barrier, regulating host immunity, and modulating gut and neuroinflammation. However, A. muciniphila was also reported to participate in the development of neuropsychiatric disorders by aggravating inflammation and influencing mucus production. Therefore, the exact mechanism of action of A. muciniphila remains much controversial. This review summarizes the proposed roles and mechanisms of A. muciniphila in various neurological and psychiatric disorders such as depression, anxiety, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, strokes, and autism spectrum disorders, and provides insights into the potential therapeutic application of A. muciniphila for the treatment of these conditions.

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Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series

Leserri,

Segura-Amil,

Nowacki

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Treatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation’s therapeutic effect may be explained through the functional and structural connectivities between the stimulated area and other brain regions, or to depression-associated networks. In this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center. We analyzed the structural and functional connectivity of the stimulation area: the structural connectivity was investigated with probabilistic tractography; the functional connectivity was estimated by combining patient-specific stimulation volumes and a normative functional connectome. These structural and functional connectivity profiles were then related to four clinical outcome scores. At 1-year follow-up, the remission rate was 66%. We observed a consistent structural connectivity to Brodmann area 25 in the patient with the longest remission phase. The functional connectivity analysis resulted in patient-specific R-maps describing brain areas significantly correlated with symptom improvement in this patient, notably the prefrontal cortex. But the connectivity analysis was mixed across patients, calling for confirmation in a larger cohort and over longer time periods.

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Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

Cited by 18 publications

References 318 publications

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome

Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series

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