Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting

McDannald, Michael A.; Kerfoot, Erin C.; Gallagher, Michela; Holland, Peter C.

doi:10.1111/j.0953-816x.2004.03458.x

Cited by 48 publications

(68 citation statements)

References 40 publications

(68 reference statements)

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“…The CN has strong projections to the hypothalamus, reticular formation, and brainstem nuclei, and so it is often argued to be involved in the arousal of behavioral, autonomic, and endocrine responses (Cardinal et al, 2002). This is consistent with other reports that CN lesions produce deficits in attentional tasks (Holland et al, 2000(Holland et al, , 2001McDannald et al, 2004), CS processing or associability (Holland and Gallagher, 1993a,b), and tasks that have assessed arousal (Merali et al, 1998;Wilhelmi et al, 2001).…”

Section: The Role Of the Amygdala In Instrumental Conditioningsupporting

confidence: 82%

Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer

Corbit¹,

Balleine²

2005

J. Neurosci.

523

593

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This series of experiments compared the effects of lesions of the basolateral complex (BLA) and the central nucleus (CN) of the amygdala on a number of tests of instrumental learning and performance and particularly on the contribution of these structures to the specific and general forms of pavlovian-instrumental transfer (PIT). In experiment 1, groups of BLA-, CN-, and sham-lesioned rats were first trained to press two levers, each earning a unique food outcome (pellets or sucrose), after which they were given training in which two auditory stimuli (tone and white noise) were paired with these same outcomes. Tests of specific satiety induced outcome devaluation, and tests of PIT revealed that, although the rats in all of the groups performed similarly during both the instrumental and pavlovian acquisition phases, BLA, but not CN, lesions abolished selective sensitivity to a change in the reward value of the instrumental outcome as well as to the selective excitatory effects of reward-related cues in PIT. In experiment 2, we developed a procedure in which both the general motivational and the specific excitatory effects of pavlovian cues could be assessed in the same animal and found that BLA lesions abolished the outcome-specific but spared the general motivational effects of pavlovian cues. In contrast, lesions of CN abolished the general motivational but spared the specific effects of these cues. Together, these results suggest that the BLA mediates outcome-specific incentive processes, whereas CN is involved in controlling the general motivational influence of reward-related events.

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Section: The Role Of the Amygdala In Instrumental Conditioningsupporting

confidence: 82%

Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer

Corbit¹,

Balleine²

2005

J. Neurosci.

523

593

View full text Add to dashboard Cite

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“…In the same study, the authors showed that the medial CeA cells retrogradely labeled from the SNc expressed an immediate-early gene, FOS, after conditioned orienting responses, demonstrating the direct involvement of the CeA to SNc projection in conditioned orienting. Furthermore, a series of studies demonstrated time dependencies such as those observed by Holland and Gallagher (2006): CeA function was critical only at the time of acquisition (McDannald et al, 2004;Groshek et al, 2005), and function of another brain region, the dorsal lateral striatum, was critical only at the time of expression of that learned response (Han et al, 1997). Most important, SNc function was critical to both the acquisition and expression of that behavior (El Almamy and Holland, 2006).…”

Section: Discussionmentioning

confidence: 95%

Role of Substantia Nigra–Amygdala Connections in Surprise-Induced Enhancement of Attention

Lee¹,

Youn²,

O³

et al. 2006

J. Neurosci.

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Coding of prediction error by midbrain dopamine neurons has been examined extensively in the framework of associative learning theory. Most of this research has focused on the role of prediction error in determining the reinforcement value of unconditioned stimuli: poorly predicted ("surprising") outcomes are more effective reinforcers and produce a greater dopamine response than well predicted outcomes. However, surprise also enhances attention to cues that signal poorly predicted outcomes. Previous reports from our laboratories demonstrated that circuitry, including the amygdala central nucleus (CeA), the cholinergic neurons of the substantia innominata/ nucleus basalis region, and their innervation of the posterior parietal cortex, is critical to these surprise-induced enhancements of attention in associative learning. The present study considered the origin of prediction error information important for the operation of this system by examining the effects of disrupting communication between the midbrain substantia nigra pars compacta (SNc) and the CeA. Rats received unilateral lesions of the SNc and lesions of the CeA in either the contralateral or ipsilateral hemisphere. Contralateral lesions eliminated the surprise-induced enhancement of attention and learning that was displayed by rats with ipsilateral control lesions. These results show that SNc-CeA communication is critical to mechanisms by which the coding of prediction error by midbrain dopamine neurons is translated into enhancement of attention and learning modulated by the cholinergic system.

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“…Within this system, the OFC and BLA are well-positioned to integrate contextrelevant multi-modal sensory input from sensory cortices with reward-related information from other mesocorticolimbic brain regions in order to guide goal-directed behaviors (Brog et al, 1993;Carmichael and Price, 1995b;Fuchs et al, 2008;McDannald et al, 2004;Price, 1986;Sah et al, 2003;Xie et al, 2010). For instance, in addition to dopaminergic input from the VTA to the OFC and BLA, glutamatergic inputs from the OFC and BLA and dopaminergic input from the VTA converge on dendritic spines of nucleus accumbens (NAc) medium spiny neurons (Kelley et al, 1982;Bouyer et al, 1984;Haber et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Lasseter

Xie

Arguello

et al. 2013

Neuropsychopharmacol

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Cocaine-seeking behavior triggered by drug-paired environmental context exposure is dependent on orbitofrontal cortex (OFC)-basolateral amygdala (BLA) interactions. Here, we present evidence supporting the hypothesis that dopaminergic input from the ventral tegmental area (VTA) to the OFC critically regulates these interactions. In experiment 1, we employed site-specific pharmacological manipulations to show that dopamine D1-like receptor stimulation in the OFC is required for drug context-induced reinstatement of cocaine-seeking behavior following extinction training in an alternate context. Intra-OFC pretreatment with the dopamine D1-like receptor antagonist, SCH23390, dose-dependently attenuated cocaine-seeking behavior in an anatomically selective manner, without altering motor performance. Furthermore, the effects of SCH23390 could be surmounted by co-administration of a sub-threshold dose of the D1-like receptor agonist, SKF81297. In experiment 2, we examined effects of D1-like receptor antagonism in the OFC on OFC-BLA interactions using a functional disconnection manipulation. Unilateral SCH23390 administration into the OFC plus GABA agonist-induced neural inactivation of the contralateral or ipsilateral BLA disrupted drug context-induced cocaine-seeking behavior relative to vehicle, while independent unilateral manipulations of these brain regions were without effect. Finally, in experiment 3, we used fluorescent retrograde tracers to demonstrate that the VTA, but not the substantia nigra, sends dense intra-and interhemispheric projections to the OFC, which in turn has reciprocal bi-hemispheric connections with the BLA. These findings support that dopaminergic input from the VTA, via dopamine D1-like receptor stimulation in the OFC, is required for OFC-BLA functional interactions. Thus, a VTA-OFC-BLA neural circuit promotes drug context-induced motivated behavior.

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Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting

Cited by 48 publications

References 40 publications

Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer

Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer

Role of Substantia Nigra–Amygdala Connections in Surprise-Induced Enhancement of Attention

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

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