2021
DOI: 10.12779/dnd.2021.20.4.99
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Amyloid Burden in Alzheimer's Disease Patients Is Associated with Alterations in Circadian Rhythm

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Cited by 7 publications
(2 citation statements)
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“…As such, an altered synchronization of circadian rhythmicity in the brain of AD patients has further reinforced the idea that circadian oscillators are key factors in the development of this devastating disorder [ 84 , 85 ]. Recent clinical evaluation of the regional distribution of Aβ in the brain by positron emission tomography-computed tomography (PET-CT) standardized uptake value ratios (SUVRs) in normal healthy, MCI and AD dementia groups showed that in AD patients, the alterations in circadian rhythms are well associated with amyloid burden [ 86 ], which provides a clear-cut indication of how alterations in circadian rhythm result in neurodegeneration due to Aβ deposition. Importantly, this phenomenon runs parallel with the declining levels of melatonin observed in AD.…”
Section: Melatonin Restores the Circadian Equipoise In Admentioning
confidence: 99%
“…As such, an altered synchronization of circadian rhythmicity in the brain of AD patients has further reinforced the idea that circadian oscillators are key factors in the development of this devastating disorder [ 84 , 85 ]. Recent clinical evaluation of the regional distribution of Aβ in the brain by positron emission tomography-computed tomography (PET-CT) standardized uptake value ratios (SUVRs) in normal healthy, MCI and AD dementia groups showed that in AD patients, the alterations in circadian rhythms are well associated with amyloid burden [ 86 ], which provides a clear-cut indication of how alterations in circadian rhythm result in neurodegeneration due to Aβ deposition. Importantly, this phenomenon runs parallel with the declining levels of melatonin observed in AD.…”
Section: Melatonin Restores the Circadian Equipoise In Admentioning
confidence: 99%
“…However, associations between self-reported sleep quality and AD biomarkers in patients with MCI have either not been demonstrated or have revealed seemingly counter-intuitive findings. Specifically, one study found no association between amyloid PET burden and self-reported sleep (Kang et al, 2021), whilst a different study reported an association between higher global PSQI scores (indicative of more impaired sleep quality) and higher plasma 42 amino acid form of amyloid-β (Aβ42) and Aβ42/Aβ40 levels (indicative of reduced AD pathology) among patients with MCI (Liu et al, 2020).…”
Section: Introductionmentioning
confidence: 99%