Amyloidosis cutis dyschromica

Abstract

Amyloidosis cutis dyschromica is a very rare form of primary cutaneous amyloidosis characterized by prepubertal onset of hyper and hypopigmented spots and amyloid deposits in the papillary dermis. We report a case of a 26 year old female with amyloidosis cutis dyschromica who presented with dyschromic skin since birth.

A rare case of late-onset amyloidosis cutis dyschromica

“…Our patient's histologic findings align with the classic histopathology of ACD. 5 Of note, macular amyloidosis has similar histologic findings, emphasizing the importance of clinical correlation. Histologic features of macular amyloidosis often include amorphous eosinophilic deposits in the papillary dermis, a characteristic also observed in ACD.…”

“… 2 A similar asymptomatic presentation with extensive reticulate hyperpigmentation and hypopigmentation was observed in another case report of 2 male siblings, aged 25 and 20, and in another case report of a 26-year-old female with lesions present since birth. 3 , 5 …”

Amyloidosis cutis dyschromica: A rare reticulate pigmentary dermatosis

“…[ 1 2 3 4 ] Freckles, telangiectasias, atrophy in the lesions and blisters have been reported rarely. [ 1 5 6 ] Poikilodermatous and bullous variants of ACD have also been documented. [ 1 ] Concomitant connective tissue disorders like systemic sclerosis, systemic lupus erythematosus and dermatomyositis and generalized morphoea as well as atypical Parkinsonism with motor weakness and spasticity with no systemic amyloidosis and colon carcinoma have been reported in the literature too.…”

“…ACD is known to be refractory to most forms of therapy despite scattered anectodal reports of efficacy of topical steroids, keratolytics, capsaicin, dimethyl sulfoxide and CO 2 laser. [ 1 2 3 4 5 6 ] Literature has shown variable efficacy of oral acitretin owing to its ability to induce apoptosis, thereby reducing the available keratinocytes, the most probable source of amyloid. Acetretin probably aids phagocytosis by macrophages, thereby ridding the dermis of amyloid.…”

Amyloidosis Cutis Dyschromica, A Rare Subtype of Primary Cutaneous Amyloidosis

“…The clinical, histopathological and treatment profile of these published cases of ACD has been compiled in Table 1 . [ 4 5 6 7 8 9 10 ]…”