Amyloidosis cutis dyschromica: A rare reticulate pigmentary dermatosis

Abstract

We are reporting a rare case of amyloidosis cutis dyschromica in a 41-year-old man. This is a rare form of primary cutaneous amyloidosis characterized by reticulate pigmentation with hypopigmented and hyperpigmented macules, onset in childhood, familial tendency in some, occasional mild itching and deposition of amyloid in the papillary dermis. Our case also had multiple bilaterally symmetrical hyperpigmented keratotic papules abutting the axillary vault resembling those seen in Dowling–Deogs disease. The other unusual feature in this patient was the strong family history of vitiligo, which we are unable to explain. We have also tried to explain the mechanism leading to the hyperpigmentation and hypopigmentation in amyloidosis cutis dyschromica.

Sporadic Dyschromatosis Universalis Hereditaria: A Second Case Report From Iran

“…In some studies, DUH has been considered to be a generalized form of a disease spectrum that includes DUH, dyschromatosis symmetrica hereditaria (confined to extremities), and a segmental form called unilateral dermatomal pigmentary dermatosis [ 4 ]. Other differential diagnoses of DUH include amyloidosis cutis dyschromica, xeroderma pigmentosum, dermatopathia pigmentosa reticularis, Naegeli-Franceschetti-Jadassohn syndrome, and dyskeratosis congenita [ 5 ]. In particular, xeroderma pigmentosum should be considered and ruled out because both diseases can involve similar body areas.…”

Progressive Pigmentation of Whole Body Mimicking Hereditary Reticulate Pigmentation in a Young Girl: A Rare Presentation of Amyloid Cutis Dyschromica

“…Differential diagnosis are dyschromatosis universalis hereditaria (DUH), xeroderma pigmentosum (XP), dyschromatosis symmetrica hereditaria (DSH), epidermolysis bullosa simplex (EBS) with mottled pigmentation , idiopathic guttate hypomelanosis (IGH) and macular amyloidosis. Macular amyloidosis and IGH can be differentiated dermoscopically (if onset after puberty) with radiating streaks, leaf like projections in former and typical well dened patterns of hypopigmented lesions namely ameboid, patelloid in latter (7) condition . XP has severe photosensitivity and other system involvement like ocular in early age.…”

Localized axillary milia en plaque: a rare cutaneous case presentation of systemic amyloidosis

“…These features typically occur on the torso or limbs. There is one previously published case of primary localized cutaneous amyloidosis occurring in the bilateral axillae as hyperpigmented and hypopigmented plaques …”