An 11-yr-old male with pneumonia and persistent airway obstruction

Niggemann, B.; Gerstner, Brett J; Guschmann, M.; Paul, K.; Wit, J C De; H, Mau; Wahn, Ulrich

doi:10.1183/09031936.02.00271602

Cited by 14 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Kesrouani et al reported successful treatment of tracheal MEC by Argon plasma coagulation with no recurrence of the tumor after 5 years [4]. Histological grade, tumor staging, and complete tumor resection are important prognostic indicators [16–18]. Moreover, Zhu et al demonstrated recently that the presence of MAML2 rearrangement within the tumor was associated with longer overall survival and disease-free survival in pulmonary MEC patients.…”

Section: Discussionmentioning

confidence: 99%

Bronchial Foreign Body Alerting of a Bronchial Tumor: The Need of a Follow-Up Radiography

El-Rifai

Shahine

Sidani

et al. 2016

Case Reports in Pediatrics

View full text Add to dashboard Cite

Lung tumors are extremely rare in the pediatric population, comprising only 0.2% of all malignancies in children. Among them, mucoepidermoid carcinoma (MEC) is even rarer with a reported frequency of 0.1% to 0.2%. MEC is defined by the World Health Organization as a tumor characterized by a combination of mucus-secreting, squamous, and intermediate cell types. We describe the case of a 4-year-old girl who presented with a history of intermittent fever and nonproductive cough of 1-month duration after foreign body aspiration. The chest X-ray showed complete collapse of the left lung. After removal of the foreign body, the lung expanded well after. However, the control chest X-ray done after 5 days showed again complete collapse of the left lung. The biopsy specimen taken during bronchoscopy confirmed the diagnosis of low-grade MEC. Fluorescence in situ hybridization (FISH) confirmed the presence of MAML2 rearrangement. Complete surgical resection with preservation of lung parenchyma was performed. No adjuvant therapy was needed. Repeat bronchoscopy was performed 2 months after surgery and showed no recurrence of the tumor. In conclusion, a remote chest X-ray after removal of a foreign body is necessary to avoid missing a rare serious underlying disease such as MEC. According to the size and the location of the tumor, complete surgical removal is sufficient without additional treatment in case of low-grade tumor. The presence of MAML2 rearrangement confers a favorable outcome and may have long-term implications for the clinical management.

show abstract

Section: Discussionmentioning

confidence: 99%

Bronchial Foreign Body Alerting of a Bronchial Tumor: The Need of a Follow-Up Radiography

El-Rifai

Shahine

Sidani

et al. 2016

Case Reports in Pediatrics

View full text Add to dashboard Cite

show abstract

“…Microscopically, the tumor cells are located in the submucosa of the large bronchi and comprise of three components: Mucus-secreting, squamous and intermediate cells. [3467] These three cell types can be organized in to different patterns including glands, tubules, cysts, nests and solid areas. The mucus-secreting cells are usually large and have light blue mucinous cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid lung carcinoma in child

Jayaprakash¹,

KishanPrasad²,

Ismail³

et al. 2014

Ann Med Health Sci Res

View full text Add to dashboard Cite

Mucoepidermoid carcinoma (MEC) is a rare malignant tumor arising from the bronchial gland. A case of 6-year-old male child who presented with fever, hemoptysis and wheezing since 1month is reported. Chest X-ray showed features suggestive of foreign body with post-obstructive pneumonia and was treated for the same with medication without much improvement. Subsequently computerized tomography scan chest was carried out, which showed oval mass with speculated margin in right hilar region with distal segmental atelectasis. Bronchoscopy showed small growth with nodularity in the apical segmental bronchus of the right lower lobe with mucosal erosion and hence carried out broncho-alveolar lavage showed few atypical squamous cells. Patient underwent right lower lobectomy, which showed a grey white oval mass with solid and cystic areas in the right hilar region with extension in to the lung parenchyma. Histology of the tumor showed mixed solid and cystic areas with sheets of epidermoid cells and mucus-filled cysts of irregular size. Areas of solid growth were composed of squamoid and intermediate cells. Hence, the final diagnosis of mucoepidermoid carcinoma (MEC) intermediate grade of the lung was made. Early diagnosis can be accomplished if the clinician is alert to persistent pneumonia, coughing and tumor obstruction on image studies. MEC is a comparatively rare low-grade tumor, which reportedly carries a good prognosis with early surgical intervention.

show abstract

“…Because no characteristic features distinguish these tumors from bronchogenic carcinoma and other benign lesions, bronchoscopy and biopsy are especially helpful in establishing the diagnosis (14,16). Mucoepidermoid carcinoma of the lung (formally called bronchial adenoma) consists 5% to 10% of these tumors (17,18). This tumor is a common salivary type of primary tumors in lung after adenoid cystic carcinoma (19).…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid Carcinoma (MEC): A Rare Cause of Chronic Cough in Children

et al. 2013

View full text Add to dashboard Cite

Introduction: Bronchial adenoma is rare in primary tumors of the lung and produce non-specific respiratory symptoms. Case Presentation: A 4-year-old boy referred to our clinic with chronic cough and wheezing. Foreign body aspiration was recommended for him on the base of radiologic and clinical manifestation. In bronchoscopy, foreign body was not detected, but an obstructing tumor was found at left lower lobe bronchial orifice. Trans bronchial biopsy, revealed a histopathologically low grade mucoepidermoid carcinoma. He underwent left lower lobectomy with safe margin. Conclusions: However, respiratory tract tumors are rare in children but can masquerade foreign body in this group. We suggest that in children of recurrent pneumonia with persistent lung infiltration, bronchial tumor should be considered.

show abstract

An 11-yr-old male with pneumonia and persistent airway obstruction

Cited by 14 publications

References 20 publications

Bronchial Foreign Body Alerting of a Bronchial Tumor: The Need of a Follow-Up Radiography

Bronchial Foreign Body Alerting of a Bronchial Tumor: The Need of a Follow-Up Radiography

Mucoepidermoid lung carcinoma in child

Mucoepidermoid Carcinoma (MEC): A Rare Cause of Chronic Cough in Children

Contact Info

Product

Resources

About