An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer

Zhang, Xianglan; Yang, Jung-Jin; Kim, Yoon Sun; Kim, Ki Yeol; Ahn, Woong Shick; Yang, Sanghwa

doi:10.3892/ijo_00000513

Cited by 27 publications

(5 citation statements)

References 27 publications

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“…In this study, we found that HSP47 mRNA and protein expression were highly upregulated in various GC cell lines and many human GC tissues. Similarly, previous studies have shown that HSP47 expression was upregulated in GC tissues [ 12 , 20 ], and HSP47 was also detected in scirrhous GC by immunohistochemical analysis [ 21 ].…”

Section: Discussionsupporting

confidence: 67%

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Lee,

Hwang,

Hong

et al. 2024

Genom. Inform.

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Here, we investigated that the heat shock protein 47 (HSP47) plays a crucial role in the progression of gastric cancer (GC). We analyzed HSP47 gene expression in GC cell lines and patient tissues. The HSP47 mRNA and protein expression levels were significantly higher in GC cell lines and tumor tissues compared to normal gastric mucosa. Using siRNA to silence the expression of HSP47 in GC cells resulted in a significant reduction in their proliferation, wound healing, migration, and invasion capacities. Additionally, we also showed that the mRNA expression of matrix metallopeptidase-7 (MMP-7), a metastasis-promoting gene, was significantly reduced in HSP47 siRNA-transfected GC cells. We confirmed that the HSP47 promoter region was methylated in the SNU-216 GC cell line expressing low levels of HSP47 and in most non-cancerous gastric tissues. It means that the expression of HSP47 is regulated by epigenetic regulatory mechanisms. These findings suggest that targeting HSP47, potentially through its promoter methylation, could be a useful new therapeutic strategy for treating GC.

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Section: Discussionsupporting

confidence: 67%

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Lee,

Hwang,

Hong

et al. 2024

Genom. Inform.

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“…Finally, great of relevance, we found an upregulation of Matrix Metalloproteinase family (MMP1, MMP3, MMP10, MMP12), that are overexpressed in gastric cancer as a result of NF-Kb activation thus promoting migration and invasion, and are associated with poor prognosis (37)(38)(39)(40). Among most downregulated genes we found GPX3, PTGER3 and LIPF (−47.5 and −435.63 of fold change for Diffuse and Intestinal tumors respectively), that resulted hypermethylated in gastric cancer (41,42).…”

Section: Patientsmentioning

confidence: 68%

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

et al. 2021

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Gastric cancer is the fifth most common malignancy but the third leading cause of cancer-associated mortality worldwide. Therapy for gastric cancer remain largely suboptimal making the identification of novel therapeutic targets an urgent medical need. In the present study we have carried out a high-throughput sequencing of transcriptome expression in patients with gastric cancers. Twenty-four patients, among a series of 53, who underwent an attempt of curative surgery for gastric cancers in a single center, were enrolled. Patients were sub-grouped according to their histopathology into diffuse and intestinal types, and the transcriptome of the two subgroups assessed by RNAseq analysis and compared to the normal gastric mucosa. The results of this investigation demonstrated that the two histopathology phenotypes express two different patterns of gene expression. A total of 2,064 transcripts were differentially expressed between neoplastic and non-neoplastic tissues: 772 were specific for the intestinal type and 407 for the diffuse type. Only 885 transcripts were simultaneously differentially expressed by both tumors. The per pathway analysis demonstrated an enrichment of extracellular matrix and immune dysfunction in the intestinal type including CXCR2, CXCR1, FPR2, CARD14, EFNA2, AQ9, TRIP13, KLK11 and GHRL. At the univariate analysis reduced levels AQP9 was found to be a negative predictor of 4 years survival. In the diffuse type low levels CXCR2 and high levels of CARD14 mRNA were negative predictors of 4 years survival. In summary, we have identified a group of genes differentially regulated in the intestinal and diffuse histotypes of gastric cancers with AQP9, CARD14 and CXCR2 impacting on patients’ prognosis, although CXCR2 is the only factor independently impacting overall survival.

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“…Zhang et al. reported that the SERPINH1 gene is upregulated in gastric cancer and can be used as a gastric cancer biomarker [18] . In lung adenocarcinoma, high SERPINH1 expression predicts poor prognosis [19] .…”

Section: Discussionmentioning

confidence: 99%

SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway

Xia,

Huang,

Zhao

et al. 2024

Translational Oncology

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An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer

Cited by 27 publications

References 27 publications

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway

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