2012
DOI: 10.4088/jcp.10m06788
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An 8-Week, Randomized Controlled Trial of Atomoxetine, Atomoxetine Plus Buspirone, or Placebo in Adults With ADHD

Abstract: clinicaltrials.gov Identifier: NCT00174226.

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Cited by 20 publications
(19 citation statements)
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“…In light of that fact, this relatively short duration may have minimized the efficacy of atomoxetine, and accordingly might have exaggerated the efficacy of sofinicline. This possibility is supported by the low effect size of atomoxetine found in this trial contrasted with effect sizes reported in many other trials of atomoxetine (0.70 --1.3) [45][46][47][48], although not all (0.4 --0.57) [49][50][51]. By comparison, the effect sizes of extended-release a agonists have been reported as 0.71 for clonidine [52] and 0.43 [53] to 0.86 [54] for guanfacine.…”
Section: Expert Opinionsupporting
confidence: 76%
“…In light of that fact, this relatively short duration may have minimized the efficacy of atomoxetine, and accordingly might have exaggerated the efficacy of sofinicline. This possibility is supported by the low effect size of atomoxetine found in this trial contrasted with effect sizes reported in many other trials of atomoxetine (0.70 --1.3) [45][46][47][48], although not all (0.4 --0.57) [49][50][51]. By comparison, the effect sizes of extended-release a agonists have been reported as 0.71 for clonidine [52] and 0.43 [53] to 0.86 [54] for guanfacine.…”
Section: Expert Opinionsupporting
confidence: 76%
“…We used the following keywords: "attention deficit hyperactivity disorder" OR "ADHD" AND "azapirone" OR "alnespirone" OR "binospirone" OR "buspirone" OR "enilospirone" OR "eptapirone" OR "gepirone" OR "ipsapirone" OR "revospirone" OR "tandospirone" OR "zalospirone". Additional eligible studies were sought from the reference lists of primary articles [9,31,[33][34][35][36][37][38] and relevant reviews [41][42][43][44].…”
Section: Inclusion Criteria Search Strategy and Data Extractionmentioning
confidence: 99%
“…In particular, buspirone increased both dopamine and noradrenaline levels in the frontal cortex of rats [29] and acted as a partial agonist at α adrenergic receptors [30]. With atomoxetine and buspirone combination therapy, it was expected that buspirone enhanced the effect of atomoxetine in increasing the extracellular levels of norepinephrine in the prefrontal cortex [31]. A recent investigation demonstrated that buspirone co-administration prevented tolerance to methylphenidate-induced cognitive enhancement in rats [32].…”
Section: Introduction ▼mentioning
confidence: 99%
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“…В настоящее время детский и подрост-ковой возраст больного (до 18 лет) является проти-вопоказанием для назначения буспирона. Однако все чаще появляются клинические исследования, в которых способность буспирона повышать актив-ность дофамина и норадреналина пытаются исполь-зовать при лечении расстройств внимания и гипе-рактивности у детей, причем как в виде монотера-пии [19,20], так и в сочетании с другими препарата-ми [21].…”
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