Turbulent combustion is one of the key processes in many energy conversion systems in modern life. In order to improve combustion efficiency and suppress emission of pollutants, many efforts have been made by scholars to investigate turbulent flames. In the present study, Artificial neural network (ANN) was first employed for the storage and interpolation of the flamelet library in flamelet generated manifolds (FGM) model, in which Eulerian stochastic field (ESF) model was used to directly consider the probability density function of the control variables. This new model had been implemented in OpenFOAM and was validated by simulation of the Sandia Flame D under consideration of the detailed chemical reaction mechanism. By comparing the results of numerical simulations and experimental measurements of the temperature and the mass fraction of main components, the accuracy of the proposed ANN-ESFFGM model was verified. Through the use of ANNs to characterize the chemical reactions, the flame simulation accuracy of the new model is higher than that of the original ESFFGM model, especially in the prediction of the ignition position. With the increase in the number of stochastic fields, the simulation accuracy of the new turbulent combustion model is continuously improved until a certain value of stochastic fields was reached. Moreover, excessively high FGM table resolution has limited improvement in numerical simulation accuracy.INDEX TERMS Artificial neural network, Eulerian stochastic field methods, Flamelet generated manifold model, OpenFOAM, turbulent combustion.