An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis

Belal, Rania; Tang, Rachel; Li, Yangping; Mabrouk, Yasser; Badr, Effat A.; Luan, Sheng

doi:10.1016/j.bbrc.2015.05.009

Cited by 26 publications

(20 citation statements)

References 37 publications

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“…hps10 was further found to be a previously identified allele (als3-3) of ALS3, which is a key determinant of plant tolerance to Al toxicity (Larsen et al, 2005). A similar result was reported by Belal et al (2015) during the course of this research. In their brief report, the latter authors also found that als3-3 was hypersensitive to Pi deficiencyinduced remodeling of root architecture, and that the sensitivity of als3-3 to Pi deficiency was sucrose dependent.…”

Section: Discussionsupporting

confidence: 83%

“…AtSTAR1 and ALS3 are the Arabidopsis counterparts of OsSTAR1 and OsSTAR2 (Huang et al, , 2010. Our work and that of Belal et al (2015) showed that like als3-3, the atstar1 mutant displays hypersensitive root responses to Pi deficiency, suggesting that AtSTAR1 and ALS3 might interact to form a common transporter complex ( Figure 4E). The similarity in the overaccumulation of Fe 3+ in roots of atstar1 and als3-3 ( Figure 5) also indicated that AtSTAR1 and ALS3 may co-exist in the same protein complex.…”

Section: Discussionmentioning

confidence: 58%

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An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots

et al. 2017

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The remodeling of root architecture is a major developmental response of plants to phosphate (Pi) deficiency and is thought to enhance a plant's ability to forage for the available Pi in topsoil. The underlying mechanism controlling this response, however, is poorly understood. In this study, we identified an Arabidopsis mutant, hps10 (hypersensitive to Pi starvation 10), which is morphologically normal under Pi sufficient condition but shows increased inhibition of primary root growth and enhanced production of lateral roots under Pi deficiency. hps10 is a previously identified allele (als3-3) of the ALUMINUM SENSITIVE3 (ALS3) gene, which is involved in plant tolerance to aluminum toxicity. Our results show that ALS3 and its interacting protein AtSTAR1 form an ABC transporter complex in the tonoplast. This protein complex mediates a highly electrogenic transport in Xenopus oocytes. Under Pi deficiency, als3 accumulates higher levels of Fe in its roots than the wild type does. In Arabidopsis, LPR1 (LOW PHOSPHATE ROOT1) and LPR2 encode ferroxidases, which when mutated, reduce Fe accumulation in roots and cause root growth to be insensitive to Pi deficiency. Here, we provide compelling evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 58%

An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots

et al. 2017

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“…A recent study, however, indicated that callose deposition in the RAM is not required for the meristem exhaustion induced by Pi deficiency . Belal et al (2015) and our group (Dong et al, 2017) recently identified another Pi-specific Arabidopsis mutant, hypersensitive to Pi starvation10 (hps10), whose PR growth is hypersensitive to Pi deficiency. HPS10 encodes the previously reported ALUMINUM SENSI-TIVE3 (ALS3), which is involved in plant tolerance to aluminum toxicity (Larsen et al, 2005).…”

mentioning

confidence: 99%

Genetic Dissection of Fe-Dependent Signaling in Root Developmental Responses to Phosphate Deficiency

Wang

Zheng

et al. 2018

Plant Physiol.

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“…A strikingly similar mechanism for an Al resistance gene leading to changes in root growth as a response to P deficiency has been proposed for ALS3 ( Larsen et al, 1996 , 2005 ) and AtSTAR1 ( Huang et al, 2010 ; Belal et al, 2015 ; Dong et al, 2017 ). Together, STAR1 and STAR2 (a rice homolog of als3 ) form an ABC transporter implicated in Al resistance likely via the transport of UDP glucose into the root apoplast, which is believed to modify the cell wall leading to Al resistance ( Huang et al, 2009 ) as previously discussed in Section “Al Resistance Transporters That do not Transport Organic Acids: Aluminum-Sensitive 3 (ALS3).” The commonality between the putative pleiotropic pathways mediated by ALMT1 and ALS3 / AtSTAR1 is striking, particularly taking into consideration that those genes underlie distinctly different Al resistance mechanisms.…”

Section: Possible Pleiotropic Effects Underlying Al Resistance and P mentioning

confidence: 55%

Emerging Pleiotropic Mechanisms Underlying Aluminum Resistance and Phosphorus Acquisition on Acidic Soils

et al. 2018

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Aluminum (Al) toxicity on acidic soils significantly damages plant roots and inhibits root growth. Hence, crops intoxicated by Al become more sensitive to drought stress and mineral nutrient deficiencies, particularly phosphorus (P) deficiency, which is highly unavailable on tropical soils. Advances in our understanding of the physiological and genetic mechanisms that govern plant Al resistance have led to the identification of Al resistance genes, both in model systems and in crop species. It has long been known that Al resistance has a beneficial effect on crop adaptation to acidic soils. This positive effect happens because the root systems of Al resistant plants show better development in the presence of soil ionic Al3+ and are, consequently, more efficient in absorbing sub-soil water and mineral nutrients. This effect of Al resistance on crop production, by itself, warrants intensified efforts to develop and implement, on a breeding scale, modern selection strategies to profit from the knowledge of the molecular determinants of plant Al resistance. Recent studies now suggest that Al resistance can exert pleiotropic effects on P acquisition, potentially expanding the role of Al resistance on crop adaptation to acidic soils. This appears to occur via both organic acid (OA)- and non-OA transporters governing a joint, iron-dependent interplay between Al resistance and enhanced P uptake, via changes in root system architecture. Current research suggests this interplay to be part of a P stress response, suggesting that this mechanism could have evolved in crop species to improve adaptation to acidic soils. Should this pleiotropism prove functional in crop species grown on acidic soils, molecular breeding based on Al resistance genes may have a much broader impact on crop performance than previously anticipated. To explore this possibility, here we review the components of this putative effect of Al resistance genes on P stress responses and P nutrition to provide the foundation necessary to discuss the recent evidence suggesting pleiotropy as a genetic linkage between Al resistance and P efficiency. We conclude by exploring what may be needed to enhance the utilization of Al resistance genes to improve crop production on acidic soils.

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An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis

Cited by 26 publications

References 37 publications

An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots

An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots

Genetic Dissection of Fe-Dependent Signaling in Root Developmental Responses to Phosphate Deficiency

Emerging Pleiotropic Mechanisms Underlying Aluminum Resistance and Phosphorus Acquisition on Acidic Soils

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