An acid-labile bridged β-CD-based nano-hydrogel with superior anti-tumor drug delivery and release capacity

Deng, Minxin; Ouyang, Cuiling; Yang, Kai; Lv, Wanwan; Huang, Tuo; Li, Xingtong; Zhou, Min; Wu, Haiqiong; Xie, Meili; Shi, Pengbo; Gao, Kai; Yi, Rongyuan; Wei, Ping; Chu, Hui; Chen, Jian

doi:10.1016/j.jddst.2022.103953

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…It can be seen from Fig 9(a) that the characteristic absorption peaks of barite are at 1185 cm -1 , 1076 cm -1 , 865 cm -1 , and 609 cm -1 . The peaks at 1185 cm -1 and 1076 cm -1 are stronger symmetric telescopic vibrational absorption peaks induced by SO 4 2 -, the peak at 865 cm -1 is an asymmetric telescopic vibrational absorption peak induced by SO 4 2- , and the peak at 609 cm -1 is an in-plane bending vibrational absorption peak [ 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Li,

Xie,

et al. 2024

PLoS ONE

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High-density waste drilling fluid contains an abundance of recyclable weighting reagents, direct disposal can pollute the environment. In this paper, the primary mineral composition of a high-density waste drilling fluid from a well in the southwest oil and gas field was analyzed. This paper proposes β-cyclodextrin (β-CD) as a depressant for the recovery of barite from waste drilling fluid. The recovery process was investigated through inverse flotation experiments, and the mechanism was analyzed using zeta potential, contact angle analysis, and FTIR. The flotation experiments showed that under the SDS flotation system, when the pH was 9.0 and the amount of depressant β-CD was 900 g/t, the barite recovery and density reached the highest values, which were 87.41% and 4.042 g/cm3, respectively. Zeta potential experiments, contact angle analysis, and FTIR analysis indicate that β-CD adsorbed onto barite through enhancing the hydrophilicity of barite, electrostatic force adsorption, and strong adsorption, which could not be displayed by SDS through competitive adsorption. Furthermore, β-CD exhibited a selective inhibitory effect on barite and enabled reverse flotation. The mechanism model of the flotation separation process was established.

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Section: Resultsmentioning

confidence: 99%

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Li,

Xie,

et al. 2024

PLoS ONE

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“…The normal cells, such as the epithelia of the human gastrointestinal tract, hair follicle cells and erythrocytes are vulnerable targets during chemotherapy, especially causing fatigue, nausea and vomiting, hair loss, and decrease in blood cells [4,5]. Even after careful treatment, chemotherapy is still restricted to killing cancer cells alone and easily leads to severe drug resistance [6,7]. Considering the serious consequences of chemotherapy on lung cancer patients as well as the improvable treatment options between chemotherapy and tumor cells, it is expected that the outcome of chemotherapy can be strengthened by targeting tumor cells rather than normal cells [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Ouyang,

Deng,

Tan

et al. 2024

Biomed. Mater.

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The traditional chemotherapeutic agents' disadvantages such as high toxicity, untargeting and poor water solubility lead to disappointing chemotherapy effects, which restricts its clinical application. In this work, novel size-appropriate and GSH-responsive nano-hydrogels were successfully prepared via the active ester method between chitosan (containing -NH2) and cross-linker (containing NHS). Especially, the cross-linker was elaborately designed to possess a disulfide linkage (SS) as well as two terminal NHS groups, namely NHS-SS-NHS. These functionalities endowed chitosan-based cross-linked scaffolds with capabilities for drug loading and delivery, as well as a GSH-responsive mechanism for drug release. The prepared nano-hydrogels demonstrated excellent performance applicable morphology, excellent drug loading efficiency (~22.5 %), suitable size (~100 nm) and long-term stability. The prepared nano-hydrogels released over 80% doxorubicin (DOX) after incubation in 10 mM GSH while a minimal DOX release less than 25% was tested in normal physiological buffer (PBS, pH = 7.4). The unloaded nano-hydrogels did not show any apparent cytotoxicity to A 549 cells. In contrast, DOX-loaded nano-hydrogels exhibited marked anti-tumor activity against A 549 cells, especially in high GSH environment. Finally, through fluorescent imaging and flow cytometry analysis, FITC-labelled nano-hydrogels show obvious specific binding to the GSH high-expressing A549 cells and nonspecific binding to the GSH low-expressing A549 cells. Therefore, with this cross-linking approach, our present finding suggests that cross-linked chitosan nano-hydrogel (CLCN) drug carrier improves the anti-tumor effect of the A 549 cells and may serve as a potential injectable delivery carrier.

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“…In addition, the side effects of antitumor drugs are a major issue in traditional chemotherapy, and these hollow tubular materials are an ideal way to reduce side effects and deliver the drugs for release at the tumor site (Lv et al, 2023). More importantly, because pH in the tumor matrix is usually more acidic than that of normal tissues and blood (with the lysosomes in tumor cells reaching an acidic of pH ~4.5-5.0; Deng et al, 2022), TiO 2 NTs with superior pHsensitive features may be feasible for controlled drug release (Feng et al, 2016;Yi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Controlled growth of titanium dioxide nanotubes for doxorubicin loading and studies of in vitro antitumor activity

Zhang

Huang

et al. 2023

Front. Bioeng. Biotechnol.

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Titanium dioxide (TiO2) materials are suitable for use as drug carriers due to their natural biocompatibility and nontoxicity. The aim of the study presented in this paper was to investigate the controlled growth of TiO2 nanotubes (TiO2 NTs) of different sizes via an anodization method, in order to delineate whether the size of NTs governs their drug loading and release profile as well as their antitumor efficiency. TiO2 NTs were tailored to sizes ranging from 25 nm to 200 nm according to the anodization voltage employed. The TiO2 NTs obtained by this process were characterized using scanning electron microscopy, transmission electron microscopy, and dynamic light scattering The larger TiO2 NTs exhibited greatly improved doxorubicin (DOX)-loading capacity (up to 37.5 wt%), which contributed to their outstanding cell-killing ability, as evidenced by their lower half-maximal inhibitory concentration (IC50). Comparisons were carried out of cellular uptake and intracellular release rates of DOX for large and small TiO2 NTs loaded with DOX. The results showed that the larger TiO2 NTs represent a promising therapeutic carrier for drug loading and controlled release, which could improve cancer treatment outcomes. Therefore, TiO2 NTs of larger size are useful substances with drug-loading potency that may be used in a wide range of medical applications.

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An acid-labile bridged β-CD-based nano-hydrogel with superior anti-tumor drug delivery and release capacity

Cited by 10 publications

References 28 publications

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Flotation recovery of barite from high-density waste drilling fluid using β-cyclodextrin as a novel depressant and its mechanism

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Controlled growth of titanium dioxide nanotubes for doxorubicin loading and studies of in vitro antitumor activity

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