An Active Agent From Rheumatoid Arthritis Synovial Tissue

Abstract

The agent in rheumatoid arthritis (RA) synovial tissue has been transmitted from individual patients to normal mice and rats by injection or ingestion. There was a variation in degree of the severity of the characteristic acute lesions in mice induced by the tissue of each individual patient. Similar characteristic lesions were induced in the same manner from RA-affected mouse and rat tissues.Neither injection nor ingestion of normal tissues induced lesions.IjTvidence has been previously pre-

Arthritis, deformities, and runting in C5-deficient mice injected with human rheumatoid arthritis synovium

“…Similar lesions were later also produced in chicks after inoculation of rheumatoid arthritis synovium homogenate into the air sacs of fertilized eggs and also in rats after ingestion of rheumatoid arthritis synovial tissue (Warren, Marmor, Boak, and Liebes, 1971;Warren, Marmor, Liebes, and Rosenblatt, 1972). We have injected homogenates of human rheumatoid arthritis synovial tissue into a C5-deficient strain of mice and have observed lesions similar to those described by Warren et al We have also observed runting of growth in some of these mice.…”