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In order to confirm and amplify the evidence of a transmissible agent in human rheumatoid arthritis (RA) tissue reported in mice experiments, data are presented indicating the transmission of the RA agent from this tissue to chicks as well as from chick to chick and by congenital transmission. Chicks hatched from injected embryonated eggs show clearly identifiable redness of the feet, talipes deformities, and dislocation of the hip. Control embryonated eggs hatched normal chicks. Roentgenograms showed developmental defects of the cervical, thoracic, lumbar, and sacral vertebrae. The chick embryo may provide an avenue to further examine the infectious etiology of RA.

The agent in rheumatoid arthritis (RA) synovial tissue has been transmitted from individual patients to normal mice and rats by injection or ingestion. There was a variation in degree of the severity of the characteristic acute lesions in mice induced by the tissue of each individual patient. Similar characteristic lesions were induced in the same manner from RA-affected mouse and rat tissues.Neither injection nor ingestion of normal tissues induced lesions.IjTvidence has been previously pre-