Congenital Deformities of Mice Transmitted by a Human Rheumatoid Synovium Agent

Warren, Stafford L.; Marmor, Leonard; Liebes, Dorothy; Hollins, Roylan L.

doi:10.1097/00003086-197005000-00028

Cited by 4 publications

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“…T h e present studies failed to confirm the reports of a transmissible agent in rhematoid synovial tissue as reported by Warren et a1 (16)(17)(18)(19). Joint lesions developed with the same degree of frequency in mice and chicks injected with either rheumatoid or nonrheumatoid material.…”

Section: Discussioncontrasting

confidence: 80%

Studies on the infectious etiology of rheumatoid arthritis

Cole

Ward

Smith

1973

Arthritis & Rheumatism

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This study was initiated in an attempt to confirm recent reports that mycoplasmas can be regularly isolated from human rheumatoid tissue, and that joint lesions can be induced in mice and chicks by injection of human rheumatoid synovium. All synovial tissues were free of mycoplasmas including T-strains. Density gradient centrifugations failed to produce additional isolates. Diphtheroids were isolated from two nonrheumatoid synovial suspensions. Joint lesions developed in 12.7% of newborn mice given rheumatoid tissue and 13.2% of mice given control material. Chick embryos injected with synovial suspensions developed a 6.7% incidence of lesions with no significant difference apparent between embryos injected with rheumatoid or nonrheumatoid synovia.In 1939, Sabin described a chronic arthritis in mice caused by a mycoplasma and suggested that human rheumatoid arthritis (RA) might have a mycoplasmal etiology (1). Since arthritis is a common manifestation of mycoplasmal diseases of animals, many studies have been undertaken to explore this possibility. However, attempts to isolate mycoplasmas from human rheumatoid materials have resulted in inconclusive findings. Using a variety of isolation procedures, Sharp (2) and Ford (3) were unable to demonstrate evidence of mycoplasma infection. O n the other hand, Bartholomew (4, 5),

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Section: Discussioncontrasting

confidence: 80%

Studies on the infectious etiology of rheumatoid arthritis

Cole

Ward

Smith

1973

Arthritis & Rheumatism

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“…[1][2][3][4] The experiments of this report were designed to determine whether the agent could be (1) transmitted from the tissues of individual rheu¬ matoid patients to mice and rats by injection; (2) transmitted from tissue taken from RA-affected mice and rats to mice and rats by injection; and (3) transmitted from tissues of individ¬ ual RA patients and affected mice and rats to mice and rats by inges¬ tion.…”

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An Active Agent From Rheumatoid Arthritis Synovial Tissue

et al. 1972

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The agent in rheumatoid arthritis (RA) synovial tissue has been transmitted from individual patients to normal mice and rats by injection or ingestion. There was a variation in degree of the severity of the characteristic acute lesions in mice induced by the tissue of each individual patient. Similar characteristic lesions were induced in the same manner from RA-affected mouse and rat tissues.Neither injection nor ingestion of normal tissues induced lesions.IjTvidence has been previously pre-

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Transmission of an Active Agent From Rheumatoid Arthritis Synovial Tissue to Chicks

Warren¹,

Marmor²,

Boak³

et al. 1971

Arch Intern Med

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In order to confirm and amplify the evidence of a transmissible agent in human rheumatoid arthritis (RA) tissue reported in mice experiments, data are presented indicating the transmission of the RA agent from this tissue to chicks as well as from chick to chick and by congenital transmission. Chicks hatched from injected embryonated eggs show clearly identifiable redness of the feet, talipes deformities, and dislocation of the hip. Control embryonated eggs hatched normal chicks. Roentgenograms showed developmental defects of the cervical, thoracic, lumbar, and sacral vertebrae. The chick embryo may provide an avenue to further examine the infectious etiology of RA.

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Congenital Deformities of Mice Transmitted by a Human Rheumatoid Synovium Agent

Cited by 4 publications

References 0 publications

Studies on the infectious etiology of rheumatoid arthritis

Studies on the infectious etiology of rheumatoid arthritis

An Active Agent From Rheumatoid Arthritis Synovial Tissue

Transmission of an Active Agent From Rheumatoid Arthritis Synovial Tissue to Chicks

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