An active role for basement membrane assembly and modification in tissue sculpting

Morrissey, Meghan A.; Sherwood, David R.

doi:10.1242/jcs.168021

Cited by 121 publications

(115 citation statements)

References 112 publications

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“…In this system, a single large protrusion was sufficient for invasion, which is mediated here by membrane displacement (Hagedorn et al, 2013). Taken together, these results might point to a new mechanism of invasion through basement membrane, which could combine protease activity and mechanical forces (Morrissey and Sherwood, 2015). Future work will be needed to determine whether these particular protrusions are indeed similar to the invadosomes described in vitro.…”

Section: Invadosome Plasticitymentioning

confidence: 66%

The microenvironment controls invadosome plasticity

Martino

Henriet

Ezzoukhry

et al. 2016

Journal of Cell Science

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Invadosomes are actin-based structures involved in extracellular matrix degradation. Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and tumour cells, respectively. They are mainly organised into dots or rosettes, and podosomes and invadopodia are often compared and contrasted. Various internal or external stimuli have been shown to induce their formation and/or activity. In this Commentary, we address the impact of the microenvironment and the role of matrix receptors on the formation, and dynamic and degradative activities of invadosomes. In particular, we highlight recent findings regarding the role of type I collagen fibrils in inducing the formation of a new linear organisation of invadosomes. We will also discuss invadosome plasticity more generally and emphasise its physio-pathological relevance.

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Section: Invadosome Plasticitymentioning

confidence: 66%

The microenvironment controls invadosome plasticity

Martino

Henriet

Ezzoukhry

et al. 2016

Journal of Cell Science

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“…Laminin deposition is the primary event of basement membrane formation, and induces the secondary assembly of the type IV collagen meshwork (Morrissey and Sherwood, 2015;Pöschl et al, 2004). In turn, the collagen IV meshwork is essential for integrity, stability and functionality of the basement membrane (Pöschl et al, 2004;Yurchenco, 2011).…”

Section: Discussionmentioning

confidence: 99%

Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly

et al. 2016

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Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized epithelial cells, are largely unknown. Here we show that assembly of the epithelial basement membrane is crucial for folliculogenesis and is controlled by endothelial cell invasion and by BMP-Smad signaling in thyrocytes. Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5 dKO ) mice displayed growth retardation, hypothyroidism and defective follicular architecture. In Smad1/5 dKO embryonic thyroids, epithelial cells remained associated in large clusters and formed small follicles. Although similar follicular defects are found in Vegfa knockout (Vegfa KO ) thyroids, Smad1/5 dKO thyroids had normal endothelial cell density yet impaired endothelial differentiation. Interestingly, both Vegfa KO and Smad1/5 dKO thyroids displayed impaired basement membrane assembly. Furthermore, conditioned medium (CM) from embryonic endothelial progenitor cells (eEPCs) rescued the folliculogenesis defects of both Smad1/5 dKO and Vegfa KO thyroids. Laminin α1, β1 and γ1, abundantly released by eEPCs into CM, were crucial for folliculogenesis. Thus, epithelial Smad signaling and endothelial cell invasion promote folliculogenesis via assembly of the basement membrane.

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“…Immunohistochemical observations revealed the presence of laminin in the two sides of the blister, thus supporting the contention of hydrolysis of the BM structure in the skin [40]. Moreover, BM hydrolysis by SVMPs is likely to affect tissue structure, since BM components, especially type IV collagen, are known to play a central role in the organization of tissue architecture [77]. Thus, alterations induced by SVMPs as a consequence of hydrolysis of BM components go beyond the acute effects associated with hemorrhage, blistering, and myonecrosis, since they also affect tissue organization and, probably, cell proliferation and regeneration occurring after tissue damage (Figure 4).…”

Section: Effects Of Svmps On the Bm: Identifying Key Protein Targementioning

confidence: 77%

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

Gutiérrez

Escalante

Rucavado

et al. 2016

Toxins

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Snake venom metalloproteinases (SVMPs) affect the extracellular matrix (ECM) in multiple and complex ways. Previously, the combination of various methodological platforms, including electron microscopy, histochemistry, immunohistochemistry, and Western blot, has allowed a partial understanding of such complex pathology. In recent years, the proteomics analysis of exudates collected in the vicinity of tissues affected by SVMPs has provided novel and exciting information on SVMP-induced ECM alterations. The presence of fragments of an array of ECM proteins, including those of the basement membrane, has revealed a complex pathological scenario caused by the direct action of SVMPs. In addition, the time-course analysis of these changes has underscored that degradation of some fibrillar collagens is likely to depend on the action of endogenous proteinases, such as matrix metalloproteinases (MMPs), synthesized as a consequence of the inflammatory process. The action of SVMPs on the ECM also results in the release of ECM-derived biologically-active peptides that exert diverse actions in the tissue, some of which might be associated with reparative events or with further tissue damage. The study of the effects of SVMP on the ECM is an open field of research which may bring a renewed understanding of snake venom-induced pathology.

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An active role for basement membrane assembly and modification in tissue sculpting

Cited by 121 publications

References 112 publications

The microenvironment controls invadosome plasticity

The microenvironment controls invadosome plasticity

Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

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