Among the major concerns in pediatric cancer patients are their emotional and social well- being arising from the unpleasant physical and psychological side effects of treatments. However, studies have shown that food preparation improves cancer patients' emotional and social well-being. The general objective of the study was [1] to assess the relationship between food preparation intervention and subjective well-being (SWB) of cancer patients, as well as [2] to determine the children's socio-emotional SWB before and after the food preparation activity implementation based on the perspectives of the patients, parents, and shelter staff'. Eight pediatric patients between 8–20 yr old, their guardians, and two shelter staff were purposively selected. A food preparation activity module was designed and implemented as part of the intervention measures. The patients, parents, and staff were interviewed to assess the patients’ emotional and social SWB before and after the activity implementation. Content and thematic analyses were used to analyze the data. The results of the study revealed that the patients’ emotional and social SWB improved right after implementation and even 3 mo after the intervention. The positive aspects of emotional SWB documented among the patients after implementation were happiness, hopefulness, gratitude, and self-confidence. The positive contributions of the activity 3 mo after its implementation were still evident. Regarding social SWB after the intervention, it was established that cooking activities encourage collaboration and social bonding among family members and the patients themselves. Three (3) mo after intervention, the patients became more outgoing, friendly, and helpful, especially towards their fellow cancer patients. The study can help researchers explore different age groups and chronic disease cases using similar food preparation activities and modules as a guide.