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With the continuous development of computer vision technology, moving object detection technology has been paid enough attention and made great progress. Many new methods and new equipment have been developed. As an important part of computer vision, it has important applications in battlefield reconnaissance, video surveillance, image compression and retrieval, human–computer interaction and other research fields, moving object detection and tracking algorithm has always been a research hotspot. We mainly study the panoramic multitarget real-time detection based on machine vision and deep learning. By studying the principle of multitarget real-time detection based on machine vision and deep learning, the panoramic multitarget real-time detection model based on machine vision and deep learning is determined. The principle and correction effect of existing image distortion correction algorithm are analyzed, and the existing problems are summarized. Aiming at the problem that the existing image distortion correction effect is not good, a new method based on machine vision and deep learning is proposed. A real-time panoramic multitarget detection method based on degree learning is proposed. The experimental results show that when the target is moving at medium speed and slow speed, the success rate of tracking is 97% and 95%, respectively; the probability of successful target detection is 100% and 97%, respectively. Experimental results show that the improved method can solve the problem of particle degradation and improve the accuracy of real-time detection.