An Adenovirus‐Mimicking Photoactive Nanomachine Preferentially Invades and Destroys Cancer Cells through Hijacking Cellular Glucose Metabolism

Feng, Shujun; Hu, Getian; Fang, Tianliang; Xie, Deqiao; Lu, Qiangbing; Xu, Yurui; Shen, Lida; Ning, Xinghai

doi:10.1002/adfm.202110092

Cited by 14 publications

(14 citation statements)

References 89 publications

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“…Particularly, the experiment was divided into four groups: PBS control, no-targeted PTT (lipoASCP under 808 nm, 1.2 W·cm –2 NIR, termed as lipoASCP + 808), mitochondria-targeted PTT (NanoValve under 808 nm, 1.2 W·cm –2 NIR, termed as NanoValve + 808), and mitochondria-targeted PTT + PDT (NanoValve under 808 nm, 1.2 W·cm –2 + 670 nm, 30 mW·cm –2 NIR, termed as NanoValve + 808 + 670). In general, normal mitochondria induce JC-1 dye aggregation to emit red fluorescence, whereas damaged mitochondria release dye to cytoplasm and exhibit green fluorescence . As shown in Figures a and S7, lipoASCP + 808-treated cells exhibited strong red fluorescence, and only weak green fluorescence signal was detected.…”

Section: Resultsmentioning

confidence: 87%

“…In general, normal mitochondria induce JC-1 dye aggregation to emit red fluorescence, whereas damaged mitochondria release dye to cytoplasm and exhibit green fluorescence. 53 As shown in Figures 5a and S7, lipoASCP + 808-treated cells exhibited strong red fluorescence, and only weak green fluorescence signal was detected. In contrast, NanoValve + 808 could effectively disrupt mitochondria and generated strong green fluorescence, indicating that mitochondria-targeted PTT effectively disrupts mitochondria.…”

Section: Photodynamic Effects Of Nanovalvementioning

confidence: 81%

“…The AuNRs were prepared according to a modified seed-mediated growth method described before; then, a modified Stöber method was used to construct the mesoporous silica coating on AuNRs, generating AuNR@SiO 2 . Subsequently, Ce6 (3 mg·mL –1 , 5 μL) was dispersed in the AuNR@SiO 2 solution (5 mL, containing 0.1 mg·mL –1 of Au) and stirred for 24 h under room temperature, then PFC (100 μL) was loaded by sonicating at 80 W for 3 min (on: 5 s, off: 1 s) in an ice-water bath, generating AuNR@Ce6 and PFC-loaded SiO 2 (ASCP).…”

Section: Methodsmentioning

confidence: 99%

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Smart Metabolism Nanovalve Reprograms Cancer Energy Homeostasis for Maximizing Photometabolism Therapy

Zhou

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Better understanding of important roles of metabolic reprogramming in therapeutic resistance provides insights into advancing cancer treatment. Herein, we present a photoactive metabolic reprogramming strategy (termed as photometabolism therapy, PMT), in which photoregulation of mitochondria leads to cancer cell metabolic crisis, and consequently overcomes therapeutic resistance while improving treatment efficacy. In specific, a stimuli-responsive metabolism NanoValve is developed for improving cascade cancer therapy through blocking mitochondrial energy supply. NanoValve is composed of an onion-like architecture with a gold nanorod core, a mesoporous silica shell encapsulating photosensitizer chlorin e6 and oxygen-saturated perfluorocarbon, and cationic liposomal coating with MMP2-cleavable polyethylene glycol corona, which together initiate mitochondria-specific PMT. NanoValve selectively responds to tumor-overexpressed MMP2 and achieves size decrease and charge reversal, which consequently enhances tumor penetration, cancer cell uptake, endosome escape, and most critically, mitochondrial accumulation. Importantly, NanoValve-mediated phototherapy can strongly destruct mitochondrial energy metabolism, thereby minimizing therapy resistance. Particularly, perfluorocarbon supplies oxygen to further overcome the tumor hypoxia-associated therapeutic barrier and maximizes synergistic anticancer effects. In vivo studies show that NanoValve can effectively eliminate tumors without side effects, thereby dramatically prolonging the survival of tumor-bearing mice. Thus, NanoValve provides a modular PMT approach and has the potential of advancing the treatment of malignancy.

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Section: Resultsmentioning

confidence: 87%

Section: Photodynamic Effects Of Nanovalvementioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Smart Metabolism Nanovalve Reprograms Cancer Energy Homeostasis for Maximizing Photometabolism Therapy

Zhou

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…Ning et al developed an adenovirus-mimicking nanomachine (AMN) consisting of AuNRs, GOD, BSA-MnO 2 , and RGD peptide for image-guided synergistic starvation therapy and PTT ( Figure 11 G ) 170 . AMN possessed adenovirus-like function, excellent cancer cell uptake, and tumor targeting capability.…”

Section: Ct Image-guided Therapymentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Nanomaterial-based CT contrast agents and their applications in image-guided therapy

Jiang¹,

Zhang²,

Li³

et al. 2023

Theranostics

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Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs and tumors because their mass attenuation coefficients are similar. Various CT contrast agents have been developed in recent years to improve the sensitivity and contrast of imaging. Here, we review the progress of nanomaterial-based CT contrast agents and their applications in image-guided therapy. The CT contrast agents are classified according to their components; gold (Au)-based, bismuth (Bi)-based, lanthanide (Ln)-based, and transition metal (TM)-based nanomaterials are discussed. CT image-guided therapy of diseases, including photothermal therapy (PPT), photodynamic therapy (PDT), chemotherapy, radiotherapy (RT), gas therapy, sonodynamic therapy (SDT), immunotherapy, starvation therapy, gene therapy (GT), and microwave thermal therapy (MWTT), are reviewed. Finally, the perspectives on the CT contrast agents and their biomedical applications are discussed.

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NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy

Yang,

Zhang,

Chang

et al. 2023

Advanced Materials

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Near‐infrared (NIR) laser‐induced photoimmunotherapy has aroused great interest due to its intrinsic non‐invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits its clinical outcomes. Although several metabolic interventions have been devoted to ameliorate immunosuppression, intracellular residual LA still remains a potential energy source for oncocyte proliferation. Herein, we construct an immunomodulatory nanoadjuvant based on a yolk‐shell CoP/NiCoP (CNCP) heterostructure loaded with the monocarboxylate transporter 4 (MCT4) inhibitor fluvastatin sodium (Flu) to concurrently relieve immunosuppression and elicit robust antitumor immunity. Under NIR irradiation, CNCP heterojunctions exhibit superior photothermal performance and photocatalytic production of reactive oxygen species (ROS) and hydrogen. The continuous heat then facilitates Flu release to restrain LA exudation from tumor cells, whereas cumulative LA can be depleted as a hole scavenger to improve photocatalytic efficiency. Subsequently, potentiated photocatalytic therapy (PCT) can not only initiate systematic immunoreaction, but also provoke severe mitochondrial dysfunction and disrupt the energy supply for heat shock protein (HSP) synthesis, in turn realizing mild photothermal therapy (PTT). Consequently, LA metabolic remodeling endows an intensive cascade treatment with an optimal safety profile to effectually suppress tumor proliferation and metastasis, which offers a new paradigm for the development of metabolism‐regulated immunotherapy.This article is protected by copyright. All rights reserved

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An Adenovirus‐Mimicking Photoactive Nanomachine Preferentially Invades and Destroys Cancer Cells through Hijacking Cellular Glucose Metabolism

Cited by 14 publications

References 89 publications

Smart Metabolism Nanovalve Reprograms Cancer Energy Homeostasis for Maximizing Photometabolism Therapy

Smart Metabolism Nanovalve Reprograms Cancer Energy Homeostasis for Maximizing Photometabolism Therapy

Nanomaterial-based CT contrast agents and their applications in image-guided therapy

NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy

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