An Adult Case of Cardiac Fibroma.

Kanemoto, Nariaki; Usui, Kazutane; Fusegawa, Yuichi

doi:10.2169/internalmedicine.33.10

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…Cardiac fibroma may mimic a broad spectrum of cardiac diseases, and the most common symptoms are congestive heart failure, heart murmur, ventricular arrhythmia, and even sudden death, most probably precipitated by ventricular fibrillation [5]. In rare cases, the tumor may be asymptomatic, with a slow clinical evolution and is diagnosed late in adulthood [6,7]. In addition, rarely, as in the present case, the tumor is encountered at autopsy.…”

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confidence: 66%

Cardiac fibroma

et al. 2001

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We present a case of cardiac fibroma encountered as an incidental finding at autopsy of an 83-year-old man without a previous clinical symptomatology. Autopsy examination of the thoracic cavity showed an enlarged heart, and a cut along the obtuse margin of the heart revealed a rather well-circumscribed, intramural mass occupying the left ventricle that measured 6×3.5×2.5 cm (Fig. 1a). The external surface was smooth, and the cut surface was hard and gray-white. No hemorrhage or necrosis was identified. The tumor tissue was obtained for both light and electron microscopy. Histologically, the tumor was not encapsulated and was composed mainly of interlacing bundles of dense collagen fibers. A few scattered spindle cells with morphological features of fibroblasts admixed with collagen fibers were recognized (Fig. 1b). The fibroblasts displayed non-atypical features, and mitoses were absent. Immunohistochemically, the cells showed a strong positivity for vimentin, whereas all other markers were negative.At the margin of the tumor, the collagen tissue intermingled with the adjacent myocardial fibers. Elastic fibers that stained red with Verrhoeff-van Gieson stain were also found (Fig. 2a). Upon electron microscopic examination, the tumor was found to be composed of abundant bundles of collagen and elastic fibers. Adjacent to collagen fibers, rare spindle-shaped cells with elongated nuclei were identified (Fig. 2b). Some of the cells had an attenuated cytoplasm but in others, the cytoplasm was more prevalent, and a rich network of rough endoplasmic reticulum was recognized. A basal lamina was not apparent. The elongated nucleus, the abundant rough endoplasmic reticulum, the absence of basal lamina, and the associated extracellular collagen were consistent with fibroblastic differentiation. Fibroblasts and collagen were seen to extend between groups of cardiac muscle fibers at the periphery of the tumor. Cardiac fibromas are rare benign tumors in adults that account for approxi-T. Vougiouklakis ( ✉ ) Fig. 1 a A heart specimen shows an intramural mass located in the left ventricle. b Fibrous conjunctive tissue with rare fibroblasts. Margin of the tumor showing the absence of a capsule and the adjacent myocardial fibers. Hematoxylin and eosin ×100

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confidence: 66%

Cardiac fibroma

et al. 2001

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“…Primary cardiac tumors are extremely rare and range in incidence from 0.0017 to 0.019% [4][5][6]. In adults, metastatic, secondary, cardiac tumors are 100-fold more frequent than primary tumors, with metastatic tumors typically arising from melanomas, lymphomas and from lung, breast or renal cancers [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations of a cardiac fibroma vary greatly and mostly depend on the size and location of the tumor. About 75% of primary benign cardiac tumors [4][5][6] and one-third of cardiac fibromas are asymptomatic and are found incidentally on imaging or in autopsy [1]. When symptoms do arise, they are usually with a triad of blood flow obstruction leading to heart failure, tumor embolization and/or constitutional symptoms [7].…”

Section: Case Reportmentioning

confidence: 99%

“…When symptoms do arise, they are usually with a triad of blood flow obstruction leading to heart failure, tumor embolization and/or constitutional symptoms [7]. Given their location, cardiac fibromas have the potential to disrupt normal electrical pathways in the heart leading to conduction defects and possibly, sudden cardiac death due to ventricular arrhythmias [1,4]. Echocardiogram and magnetic resonance imaging should be performed to describe the tumor and a treatment plan should be formulated in order to avoid potential lethal complications [3].…”

Section: Case Reportmentioning

confidence: 99%

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Unusual Cause of a Left Ventricular Mass in an Octogenarian with Metastatic Squamous Cell Lung Cancer

J¹,

D²,

Pranjal³

et al. 2022

Int J Clin Cardiol

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“…Rhabdomyomas are associated with tuberous sclerosis and may be caused by a defect in cellular apoptosis. Like rhabdomyomas, fibromas also originate within the myocardium but tend to occur in the free ventricular wall and are composed of fibrous connective tissue that may calcify and demonstrate characteristic whorls under light microscopy (51,52). The Gorlin syndrome is associated with fibromas and is an autosomal dominant disorder that also includes basal cell carcinomas, medulloblastomas, and fibrous histiocytomas.…”

Section: Review Of Cardiac Tumorsmentioning

confidence: 99%

Cardiovascular Magnetic Resonance of Primary Tumors of the Heart: A Review

Fieno¹,

Saouaf²,

Thomson³

et al. 2006

Journal of Cardiovascular Magnetic Resonance

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Overall, the prevalence of primary cardiac neoplasms is approximately 0.3% and these masses should be distinguished from the myriad of other primary and secondary processes that can occur in the heart. Tumors within, attached to, or near the heart can cause direct cardiac damage, can result in thrombus formation, can compromise blood flow and can embolize distally. Hence, proper diagnosis is clinically important. It has been suggested that cardiovascular magnetic resonance (CMR) imaging is a useful tool for diagnosing and characterizing cardiac tumors. In this report, we present a case example of a patient with a large, mobile right atrial myxoma imaged by CMR with results of histopathologic analysis after excision. We also demonstrate the utilization of CMR for characterization of cardiac lesions, review the basic characteristics of primary cardiac neoplasms, provide an overview of published cases describing use of CMR, and give suggested guidelines for imaging of cardiac masses with emphasis on diagnosis of cardiac tumors. CMR is an important technique for diagnosing and characterizing cardiac tumors.

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An Adult Case of Cardiac Fibroma.

Cited by 8 publications

References 8 publications

Cardiac fibroma

Cardiac fibroma

Unusual Cause of a Left Ventricular Mass in an Octogenarian with Metastatic Squamous Cell Lung Cancer

Cardiovascular Magnetic Resonance of Primary Tumors of the Heart: A Review

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