An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic Infection

Miyoshi, Toru; Hiraoka, Atsushi; Hidaka, Shigekazu; Shimizu, Yuko; Ninomiya, Keiko; Utsunomiya, Hiroki; Tazuya, Nayu; Tanihira, Tetsuya; Hasebe, Aki; Miyamoto, Yoshinori; Nakamura, Tomoyuki; Abe, Masanori; Hiasa, Yoichi; Onji, Morikazu; Michitaka, Kojiro

doi:10.2169/internalmedicine.51.6142

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…They did not take any medicine that may suppress immune functions. The details of the clinical courses and complete nucleotide sequences of HBV in patients 2 and 3 have been reported previously as case reports [ 17 – 19 ]. In patient 1, precore (nt 1986) and core promoter (nt 1762 and nt 1764) sequence of HBV-DNA were analyzed by polymerase chain reaction-enzyme-linked minisequence assay (PCR-ELMA) and PCR-scintillation proximity assay (PCR-SPA), respectively.…”

Section: Resultsmentioning

confidence: 99%

Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection

Michitaka

Hiraoka

Terada

et al. 2014

International Journal of Hepatology

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Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection.

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Section: Resultsmentioning

confidence: 99%

Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection

Michitaka

Hiraoka

Terada

et al. 2014

International Journal of Hepatology

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Prioritising immunisations for travel: International and Japanese perspectives

Kimura

Fujii

Carroll

2014

Travel Medicine and Infectious Disease

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Acute hepatitis B of genotype H resulting in persistent infection

Yamada

Shigefuku

Sugiyama

et al. 2014

WJG

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A 47-year-old man presented with general fatigue and dark urine. The laboratory data showed increased levels of hepatic transaminases. The patient was positive for hepatitis B virus (HBV) markers and negative for anti-human immunodeficiency virus. The HBV-DNA titer was set to 7.7 log copies/mL. The patient was diagnosed with acute hepatitis B. The HBV infection route was obscure. The serum levels of hepatic transaminases decreased to normal ranges without any treatment, but the HBV-DNA status was maintained for at least 26 mo, indicating the presence of persistent infection. We isolated HBV from the acute-phase serum and determined the genome sequence. A phylogenetic analysis revealed that the isolated HBV was genotype H. In this patient, the elevated peak level of HBV-DNA and the risk alleles at human genome single nucleotide polymorphisms s3077 and rs9277535 in the human leukocyte antigen-DP locus were considered to be risk factors for chronic infection. This case suggests that there is a risk of persistent infection by HBV genotype H following acute hepatitis; further cases of HBV genotype H infection must be identified and characterized. Thus, the complete determination of the HBV genotype may be essential during routine clinical care of acute hepatitis B outpatients.

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An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic Infection

Cited by 3 publications

References 16 publications

Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection

Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection

Prioritising immunisations for travel: International and Japanese perspectives

Acute hepatitis B of genotype H resulting in persistent infection

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