An “AIE + ESIPT” mechanism-based benzothiazole-derived fluorescent probe for the detection of Hg²⁺and its applications

Abstract

Mercury ion (Hg2+) contamination is very hazardous and harmful to the natural environment and human health. The development of small molecule fluorescent probes for rapid detection of Hg2+ is of...

Heterocyclic molecules with ESIPT emission: synthetic approaches, molecular diversities, and application strategies

“…NMR and high-resolution mass spectroscopy (HRMS) were used to validate the release mechanism with the addition of Hg 2+ to the probe solution. ( Scheme 3A ) [ 16 ]. A suitable probe for mercury detection, 4a , was developed by replacing the methoxy group on the benzene ring in compound 4b with an aldehyde group.…”

A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift

“…7 Thus, a variety of fluorescent probes have been developed for Hg 2+ detection, based on either coordination 8 or specific reactions. 9–17 Compared with the former, reaction-based fluorescent probes usually display high selectivity for Hg 2+ due to the high specificity of the reactions, including replacement of arylboronic acid, 10 oxymercuration, 11 deprotection of mercaptal 12 or vinyl ether, 13 desulfurization, 14 desulfurization-cyclization, 15 and desulfurization-hydrolysis. 16,17 However, some reaction-based Hg 2+ -specific fluorescent probes have one or more drawbacks, such as small Stokes shifts, long response times, non-physiological pH, tedious synthesis, and purification process.…”

“…9–17 Compared with the former, reaction-based fluorescent probes usually display high selectivity for Hg 2+ due to the high specificity of the reactions, including replacement of arylboronic acid, 10 oxymercuration, 11 deprotection of mercaptal 12 or vinyl ether, 13 desulfurization, 14 desulfurization-cyclization, 15 and desulfurization-hydrolysis. 16,17 However, some reaction-based Hg 2+ -specific fluorescent probes have one or more drawbacks, such as small Stokes shifts, long response times, non-physiological pH, tedious synthesis, and purification process. It has been reported that Hg 2+ is predominant in mitochondria, 15 b ,16 c ,18 which not only decreases the mitochondrial membrane potential, but also causes cell apoptosis owing to its binding to thiol-containing proteins.…”

A fluorescent probe based on an enhanced ICT effect for Hg2+ detection and cell imaging

“…[5][6][7] Many studies have shown that long-term intake of Hg 2+ can lead to various diseases of the nervous system and eventually to death in humans. [8][9][10][11][12][13][14] Therefore, a rapid detection method for Hg 2+ is urgently needed to ensure environmental and social development.…”