An alginate-poly(acrylamide) hydrogel with TGF-β3 loaded nanoparticles for cartilage repair: Biodegradability, biocompatibility and protein adsorption

Saygili, Ecem; Kaya, Elif; Ilhan‐Ayisigi, Esra; Sağlam-Metiner, Pelin; Alarçin, Emine; Kazan, Aslihan; Girgic, Ezgi; Kim, Yong-Woo; Gunes, Kasim; Eren-Ozcan, Guler Gamze; Akakın, Dilek; Sun, Jeong‐Yun; Yeşil-Çeliktaş, Özlem

doi:10.1016/j.ijbiomac.2021.01.069

Cited by 55 publications

(29 citation statements)

References 69 publications

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“…Saygili et al prepared a functionalized polyacrylamide (PAAM)-ALG double network hydrogel [ 77 ]. Subsequently, the PLGA NPs loaded with functional transformation factors were encapsulated in this hydrogel, similar to articular tissue, and maintained their mechanical stability for over 3 months at different temperatures (+4, 25, 40 °C) and humidity conditions (60% and 75%).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field. The present review provides an overview of the properties and processing methods of alginates, as well as their applications in wound healing, tissue repair and drug delivery in recent years.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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“…It has also been proved that alginate-polyacrylamide showed good tribological behavior, ultra-low coefficient, and high wear-resistance [86]. After transplantation, chondrocytes displayed an organized distribution and superior integration with surrounding tissue (Figure 6) [87]. Alginate and its composites provide chondrogenic differentiation and cell proliferation, therefore, these hybrid gels can be used as cartilage implants.…”

Section: Cartilagementioning

confidence: 95%

Alginate-Based Composite and Its Biomedical Applications

Deng¹,

Yang²,

Okoro³

et al. 2022

Properties and Applications of Alginates

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Alginate has received much attention due to its biocompatibility. However, the properties of pure alginate are limited, such as weak mechanical strength, which limits its application. Alginate-based composite effectively overcomes the defect of pure alginate. The molecular weight and microstructure can be designed. More importantly, the essential properties for clinical application are improved, including mechanical properties, biocompatibility, gelation ability, chondrogenic differentiation and cell proliferation. This chapter will describe development of alginate-based composite in biomedical application. In the fields of wound dressing, drug delivery, and tissue engineering, the impact of structural changes on performance has been stated. To provide readers with understanding of this chapter, the structure and characterization of alginate will be included.

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“…Saygili et al (2021) developed a hydrogel composed of alginate and PAM for the in situ delivery of the transforming growth factor beta-3 (TGF-β3) for cartilage regeneration [ 49 ]. The growth factor was entrapped in PLGA NPs, and the experimental parameters were optimized to yield NPs with suitable dimensions.…”

Section: Routes Of Drugs Administrationmentioning

confidence: 99%

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

et al. 2022

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Clinically available medications face several hurdles that limit their therapeutic activity, including restricted access to the target tissues due to biological barriers, low bioavailability, and poor pharmacokinetic properties. Drug delivery systems (DDS), such as nanoparticles (NPs) and hydrogels, have been widely employed to address these issues. Furthermore, the DDS improves drugs’ therapeutic efficacy while reducing undesired side effects caused by the unspecific distribution over the different tissues. The integration of NPs into hydrogels has emerged to improve their performance when compared with each DDS individually. The combination of both DDS enhances the ability to deliver drugs in a localized and targeted manner, paired with a controlled and sustained drug release, resulting in increased drug therapeutic effectiveness. With the incorporation of the NPs into hydrogels, it is possible to apply the DDS locally and then provide a sustained release of the NPs in the site of action, allowing the drug uptake in the required location. Additionally, most of the materials used to produce the hydrogels and NPs present low toxicity. This article provides a systematic review of the polymeric NPs-loaded hydrogels developed for various biomedical applications, focusing on studies that present in vivo data.

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An alginate-poly(acrylamide) hydrogel with TGF-β3 loaded nanoparticles for cartilage repair: Biodegradability, biocompatibility and protein adsorption

Cited by 55 publications

References 69 publications

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Alginate-Based Composite and Its Biomedical Applications

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

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