With its boundary tracing out a link or knot in 3D, the Seifert surface is a 2D surface of core importance to topological classification. We propose the first-ever experimentally realistic setup where Seifert surfaces emerge as the boundary states of 4D topological matter. Unlike ordinary real space knots that exist in polymers, biomolecules and everyday life, our knots and their Seifert surfaces exist as momentum space nodal structures, where topological linkages have profound effects on optical and transport phenomena. Realized with 4D circuit lattices, our nodal Seifert systems are freed from symmetry constraints and readily tunable due to the dimension and distance agnostic nature of circuit connections. Importantly, their Seifert surfaces manifest as very pronounced impedance peaks in their 3D-imaging via impedance measurements, and are directly related to knot invariants like the Alexander polynomial and knot Signature. This work thus unleashes the great potential of Seifert surfaces as sophisticated yet accessible mathematical tools in the study of exotic band structures.