An Algorithmic Approach to Chronic Cough

Pratter, Melvin R.

doi:10.7326/0003-4819-119-10-199311150-00003

Cited by 238 publications

(195 citation statements)

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“…Several prospective studies have demonstrated asthma to be among the most common causes of chronic cough (24-29%) in nonsmoking adults [6,12,50]. Usually, cough is associated with the more typical symptoms of dyspnoea and wheezing.…”

Section: Asthmatic Cough and Eosinophilic Bronchitismentioning

confidence: 99%

The diagnosis and management of chronic cough

Morice¹

2004

Eur Respir J

468

360

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Section: Asthmatic Cough and Eosinophilic Bronchitismentioning

confidence: 99%

The diagnosis and management of chronic cough

Morice¹

2004

Eur Respir J

468

360

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“…In addition, nasal challenge with menthol is known to diminish cough reflex sensitivity and urge-to-cough sensation in healthy volunteers [67]. Empirical therapy with first-generation antihistamines (with or without a decongestant) has proved to be a successful approach [68], although questions remain as to whether this is due to the amelioration of the underlying disorder or to an intrinsic antitussive effect of these agents [69].…”

Section: Question 13mentioning

confidence: 99%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions.There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough.The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area. @ERSpublications Cough hypersensitivity syndrome was clearly endorsed by opinion leaders as a valid and useful concept

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“…The present study indicates that PSE might be useful for patients suffering from unnecessary cough. In fact, it is reported that the use of PSE as decongestant improves chronic cough, while the newer antihistamines are ineffective (32). This may be due to the antitussive effect rather than any decongestive effect of PSE.…”

Section: Discussionmentioning

confidence: 94%

Effect of d-Pseudoephedrine on Cough Reflex and Its Mode of Action in Guinea Pigs

Minamizawa¹,

Goto²,

Ohi³

et al. 2006

J Pharmacol Sci

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Abstract. d-Pseudoephedrine (PSE) is one of the main ingredients of Ephedrae herba. Although PSE is widely applied for patients with a common cold and upper respiratory inflammation as a decongestant, the effects of PSE on cough have never been reported. In this study, we investigated the antitussive effects of intraperitoneal injection of PSE on the cough reflex induced by microinjection of citric acid into the larynx of guinea pigs. PSE decreased the number of cough reflexes dose-dependently (−18.3 ± 5.0% at 20 mg / kg, P<0.05; −41.1 ± 7.2% at 60 mg / kg, P<0.01). Furthermore, PSE (60 mg / kg) increased the threshold intensity for inducing fictive cough by electrical micro-stimulation of the nucleus tractus solitarius (+72.7 ± 8.4%, P<0.01). On the afferent discharge of the superior laryngeal nerve, PSE suppressed the increases of amplitude and frequency when stimulated by citric acid at laryngeal mucosa. These results demonstrate that PSE possesses an antitussive effect that might be derived from both central and peripheral actions.

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An Algorithmic Approach to Chronic Cough

Cited by 238 publications

References 0 publications

The diagnosis and management of chronic cough

The diagnosis and management of chronic cough

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Effect of d-Pseudoephedrine on Cough Reflex and Its Mode of Action in Guinea Pigs

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