An alternative method for fire smoke toxicity assessment using human lung cells

Lestari, Fatma; Green, A.R.; Chattopadhyay, Goutami; Hayes, Amanda

doi:10.1016/j.firesaf.2006.06.001

Cited by 36 publications

(43 citation statements)

References 39 publications

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“…For in vitro studies intended to probe particle toxicity associated with inhalation exposure, this approach is thought to be more physiologically realistic compared to exposure in a liquid suspension. This technique has been used to investigate tobacco smoke [29], diesel exhaust [30, 31], smoke from building material combustion [32], flame-generated cerium oxide nanoparticles [33], metal salt nanoparticles [34], and magnetic nanoparticles [35]. …”

Section: Introductionmentioning

confidence: 99%

Toxicity of Silver Nanoparticles at the Air-Liquid Interface

Holder

Marr

2013

BioMed Research International

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Silver nanoparticles are one of the most prevalent nanomaterials in consumer products. Some of these products are likely to be aerosolized, making silver nanoparticles a high priority for inhalation toxicity assessment. To study the inhalation toxicity of silver nanoparticles, we have exposed cultured lung cells to them at the air-liquid interface. Cells were exposed to suspensions of silver or nickel oxide (positive control) nanoparticles at concentrations of 2.6, 6.6, and 13.2 μg cm−2 (volume concentrations of 10, 25, and 50 μg ml−1) and to 0.7 μg cm−2 silver or 2.1 μg cm−2 nickel oxide aerosol at the air-liquid interface. Unlike a number of in vitro studies employing suspensions of silver nanoparticles, which have shown strong toxic effects, both suspensions and aerosolized nanoparticles caused negligible cytotoxicity and only a mild inflammatory response, in agreement with animal exposures. Additionally, we have developed a novel method using a differential mobility analyzer to select aerosolized nanoparticles of a single diameter to assess the size-dependent toxicity of silver nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Toxicity of Silver Nanoparticles at the Air-Liquid Interface

Holder

Marr

2013

BioMed Research International

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“…Nekatere raziskave so dokazale, da ima PVC rakotvorni učinek in negativen vpliv na reprodukcijo (71,72). Pregled raziskav o vplivu materialov PVC v izrednih situacijah, kot je požar, je dokazal, da pri gorenju PVC nastanejo vodikov klorid in drugi škodljivi produkti gorenja (73).…”

Section: Kemični Dejavniki Tveganja Za Zdravjeunclassified

Identification and Control of Health Risks in Hospital Environment from the Aspect of Users, Buildings and Systems

Dovjak¹,

Kukec²,

Krainer³

2013

Slovenian Journal of Public Health

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“…Dampak dari berbagai senyawaan produk pembakaran diketahui sangat toksik dan berbahaya bagi kesehatan serta sel manusia [5]. …”

Section: Pendahuluanunclassified

Audit Sarana Prasarana Pencegahan Penanggulangan Dan Tanggap Darurat Kebakaran Di Gedung Fakultas X Universitas Indonesia Tahun 2006

Lestari¹,

Panindrus²

2010

MST

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AbstrakKebakaran dapat menyebabkan kerugian baik jiwa, material dan aset berharga. Penelitian ini bertujuan untuk mengaudit manajemen kebakaran dan sistem tanggap darurat di gedung Fakultas X -Universitas Indonesia Depok. Hasil audit terhadap sarana dan prasarana kebakaran serta sistem tanggap darurat selanjutnya dibandingkan terhadap Building Code Australia (BCA) dan Peraturan dan Ketentuan teknis pengamanan terhadap bahaya kebakaran pada bangunan gedung Kep.MenPU.No 10/KPTS/2000. Gedung yang diaudit terdiri dari Gedung A, B, C, D, F dan G. Klasifikasi gedung A, B, D, F, dan G merupakan Kelas 5 sedangkan gedung C merupakan kelas 9b. Variabel yang diaudit adalah jalan keluar, struktur bangunan, sistem detektor dan alarm, sistem komunikasi dan peringatan darurat kebakaran, prosedur evakuasi, peralatan pemadam kebakaran seperti alat pemadam api ringan (APAR), hidran, springkler, serta sistem tanggap darurat. Hasil penelitian menunjukkan bahwa jalan keluar belum memenuhi persyaratan karena terkunci. Struktur bangunan secara umum sudah memenuhi persyaratan karena merupakan konstruksi beton bertulang. Sistem detektor dan alarm hanya terdapat pada gedung G, sedangkan gedung lainnya belum memenuhi persyaratan (belum tersedia, rusak, atau tidak berfungsi). Pada gedung G terdapat sistem komunikasi dan peringatan darurat kebakaran, namun pada gedung lain belum tersedia. Belum terdapat metode dan prosedur evakuasi untuk pengosongan gedung. Peralatan pemadam kebakaran khususnya APAR sudah tersedia dan memenuhi persyaratan pada semua gedung, namun untuk hidran dan springkler hanya tersedia di gedung G. Belum tersedianya sistem tanggap darurat di fakultas ini. Dari hasil penelitian diperoleh kesimpulan bahwa sarana dan prasarana penanggulangan kebakaran pada fakultas ini masih perlu ditingkatkan. AbstractBuilding Fire Safety Audit at Faculty X, University of Indonesia, Year 2006. Fire may cause loss of life, material and valuable assets. The objective of this study is to conduct audit for fire safety and emergency response in the building at

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An alternative method for fire smoke toxicity assessment using human lung cells

Cited by 36 publications

References 39 publications

Toxicity of Silver Nanoparticles at the Air-Liquid Interface

Toxicity of Silver Nanoparticles at the Air-Liquid Interface

Identification and Control of Health Risks in Hospital Environment from the Aspect of Users, Buildings and Systems

Audit Sarana Prasarana Pencegahan Penanggulangan Dan Tanggap Darurat Kebakaran Di Gedung Fakultas X Universitas Indonesia Tahun 2006

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