An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits

Lan, Xianyong; Pan, Chuanying; Chen, H.; Zhang, C.L.; Li, J.Y.; Zhao, Miao; Lei, Chuzhao; A, Zhang, A.L.,Northwest; Zhang, L.

doi:10.1016/j.smallrumres.2006.10.009

Cited by 145 publications

(101 citation statements)

References 10 publications

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“…Genomic DNA was isolated from whole blood or ear tissues following the procedure described by Lan et al (2007) and Pan et al (2013). The concentration of genomic DNA was quantified and the working solution of each DNA samples was 50 ng/μL .…”

Section: Animals and Growth Traitsmentioning

confidence: 99%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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Polymorphisms in the prion protein gene (PRNP) have been linked with the occurrence of transmissible spongiform encephalopathies and the expression of some phenotypic traits in healthy animals including cattle. The aim of this study was to verify the 23-bp insertion/deletion (indel) within promoter region and the 12-bp indel within intron 1 of PRNP, as well as to evaluate their associations with growth traits. Two loci of PRNP were genotyped in 1558 healthy Chinese cattle sampled from 6 indigenous breeds. Moreover, phenotypic records for growth were used to find the relationship between PRNP polymorphisms and phenotypic performance. The results confirmed the occurrence of these two indel polymorphisms in the analysed breeds. Association analysis showed that the 23-bp indel was significantly related to the body length and heart girth in 18-months-old Nanyang cattle. The 12-bp indel was significantly related to the growth traits in three cattle breeds, such as the body weight in Xia'nan cattle, the daily gained weight in 12-months-old Nanyang cattle and the cannon circumference and rump length in Ji'an cattle. These findings indicated that these two indels may affect bovine growth traits, which could benefit to healthy cattle selection and breeding through marker-assisted selection.

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Section: Animals and Growth Traitsmentioning

confidence: 99%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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“…Moreover, the mutations of the LHX4 gene are also associated with dominantly inherited GH deficiency. To date, LHX4-driven pathway could have influenced the expression of GH (Machinis and Amselem, 2005), POU1F1, PRL, and other genes which are closely related to reproduction of livestock (Wu and Xu, 2000;Lan et al, 2007;Yang et al, 2017). Therefore, the LHX4 gene was possibly associated with CPHD and reproduction traits in livestock.…”

Section: Introductionmentioning

confidence: 99%

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

et al. 2018

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Abstract. The LIM homeobox transcription factor 4 (LHX4) gene plays a critical role in regulating the development of the pituitary and the secretion of growth hormone (GH) and prolactin (PRL) associated with reproduction. Thus this gene may affect litter size. Herein, the aim of this study is to detect the novel insertion/deletion (indel) within the LHX4 gene as well as to test its association with litter size in 1149 Shaanbei white cashmere goats. Herein, a novel 12 bp indel (NC_030823.1:g.60001011_60001022delGGGGAGGAGGGG) was firstly found, which was located in the first intron. Meanwhile, three genotypes were detected in Shaanbei white cashmere goats, and the allelic frequencies of I and D were 0.593 and 0.407, respectively. Interestingly, the genotype distributions between mothers of single-lamb (n = 895) and multi-lamb (n = 254) groups within Shaanbei white cashmere goats were significantly different, implying that the 12 bp indel might affect the litter size. Furthermore, the association analysis was carried out to find out that the 12 bp indel was significantly associated with litter size in the analyzed goat population (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II (P < 0.05). These findings suggest that this locus could be considered as a genetic marker for goat breeding, enriching the research category of functional genome of goats.

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“…For example, the synonymous mutation AC_000163:g.18161C>G SNP in the goat PITX2 gene is associated with milk density in the Guanzhong dairy goat (Zhao et al, 2013). The synonymous mutation might produce codon usage bias, thereby influencing the production traits (Lan et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The genes mentioned above, CLPG, STAT3, STAT5A, POU1F1 and PROP1, all have SNPs associated with growth traits, and some SNP genotypes were found to be significantly associated with mRNA expression levels (Jia et al, 2015;Lan et al, 2007Lan et al, , 2009Wu et al, 2014;Zhao et al, 2013). In humans, functional SNPs that were associated with disease were found in the ATBF1 gene (Liu et al, 2014;Tsai et al, 2015).…”

mentioning

confidence: 99%

Evaluation of novel SNPs and haplotypes within the <i>ATBF1</i> gene and their effects on economically important production traits in cattle

Zhang

et al. 2017

Arch. Anim. Breed.

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Abstract. AT motif binding factor 1 (ATBF1) gene can promote the expression level of the growth hormone 1 (GH1) gene by binding to the enhancers of the POU1F1 and PROP1 genes; thus, it affects the growth and development of livestock. Considering that the ATBF1 gene also has a close relationship with the Janus kinasesignal transductor and activator of transcription (JAK-STAT) pathway, the objective of this work was to identify novel single-nucleotide polymorphism (SNP) variations and their association with growth traits in native Chinese cattle breeds. Five novel SNPs within the ATBF1 gene were found in 644 Qinchuan and Jinnan cattle for first time using 25 pairs of screening and genotyping primers. The five novel SNPs were named as AC_000175:g.140344C>G (SNP1), g.146573T>C (SNP2), g.205468C>T (SNP3), g.205575A>G (SNP4) and g.297690C

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An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits

Cited by 145 publications

References 10 publications

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

Evaluation of novel SNPs and haplotypes within the <i>ATBF1</i> gene and their effects on economically important production traits in cattle

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An AluI PCR-RFLP detecting a silent allele at the goat POU1F1 locus and its association with production traits

Cited by 145 publications

References 10 publications

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

Evaluation of novel SNPs and haplotypes within the &lt;i&gt;ATBF1&lt;/i&gt; gene and their effects on economically important production traits in cattle

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A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

Evaluation of novel SNPs and haplotypes within the <i>ATBF1</i> gene and their effects on economically important production traits in cattle