This paper proposes that an organism's integrated repertoire of operant behavior has the status of a biological system, similar to other biological systems, like the nervous, cardiovascular, or immune systems. Evidence from a number of sources indicates that the distinctions between biological and behavioral events is often misleading, engendering counterproductive explanatory controversy. A good deal of what is viewed as biological (often thought to be inaccessible or hypothetical) can become publicly measurable variables using currently available and developing technologies. Moreover, such endogenous variables can serve as establishing operations, discriminative stimuli, conjoint mediating events, and maintaining consequences within a functional analysis of behavior and need not lead to reductionistic explanation. I suggest that explanatory misunderstandings often arise from conflating different levels of analysis and that behavior analysis can extend its reach by identifying variables operating within a functional analysis that also serve functions in other biological systems.Key words: functional systems, scientific explanation, neuroscience, reductionismSince its inception, the field of behavior analysis has been concerned primarily with variables external to the organism that influence its behavior. Endogenous factors have largely been considered private, inaccessible, and in some cases, hypothetical (Skinner, 1938), a view that persists today (e.g., BarnesHolmes, 2005;Faux, 2002). These distinctions are contrary to the epistemology of a functional analysis of behavior, which attempts to identify the functions of variables in relation to observable behavior, not their physical locus or ease of accessibility to public scrutiny. Dividing an organism's world into behavioral and biological factors has created counterproductive explanatory problems, often presented as a conflict between reductionism and explanation based on publicly accessible external variables (Moore, 2002). The main purpose of this paper is to suggest that an organism's integrated repertoire of operant behavior has the status of a biological system, similar to other systems, like the nervous, cardiovascular, or immune systems. This collective system of functional behavioral units (see Thompson & Zeiler, 1986) provides the major mechanism by which organisms interact with, and act upon their physical and social environments. A second purpose is to present evidence that the distinctions between biological and behavioral events are often misleading, since a good deal of what is often viewed as biological (often believed to be inaccessible or hypothetical) can be made publicly measurable using currently available and developing technologies. Finally, I suggest that misunderstandings arise from conflating different levels of analysis and their associated causal relationships.The integrated repertoire of behavioral units (operants) that have been acquired and maintained under the functional control of motivational or establishing operations, discri...