An analysis of etiology, causal pathogens, imaging patterns, and treatment of Japanese patients with bronchiectasis

Kadowaki, Toru; Yano, Shuichi; Wakabayashi, Kiryo; Kobayashi, Kanako; Ishikawa, Shigenori; Kimura, Masahiro; Ikeda, Toshikazu

doi:10.1016/j.resinv.2014.09.004

Cited by 30 publications

(29 citation statements)

References 24 publications

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“…Like the Thai patients, South Koreans also had a significant prevalence of K. pneumoniae [97]. While geographically close; work from Japan however reports P. aeruginosa as the predominant airway bacteria (24%) closely followed by only moderate levels of NTM (19%) [37]. Interestingly, in the Pacific region, specifically central and southern Australia; reported rates of H. influenzae (36-81%) compared to P. aeruginosa (7-26%) are higher with very low occurrences of NTM (1-2%) [88,98,99].…”

Section: The Bronchiectasis Bacteriome In the Asia-pacific Regionmentioning

confidence: 92%

“…Important aetiologies of bronchiectasis seen in other regions including immunodeficiency syndromes such as, common variable immunodeficiency, secondary immunoglobulin disorders (frequently drug related) and mucociliary defects including primary ciliary dyskinesia, chronic aspiration, autoimmune/connective tissue diseases, particularly rheumatoid arthritis, and ABPA are described and in some cases result in a delayed diagnoses. In Japan, a less studied inflammatory disease, sinobronchial syndrome is documented in many cases of bronchiectasis [37].…”

Section: Bronchiectasis In the Asia-pacific Regionmentioning

confidence: 99%

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Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

et al. 2018

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Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations. Modern molecular technologies including next generation sequencing (NGS) have become invaluable tools to identify microorganisms directly from sputum and which are difficult to culture using traditional agar based methods. These have provided important insight into our understanding of emerging pathogens in the airways of people with bronchiectasis and the geographical differences that occur. The contribution of the lung microbiome, its ethnic variation, and subsequent roles in disease progression and response to therapy across geographic regions warrant further investigation. This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis. Further, we highlight the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic differences in the prognosis and management of bronchiectasis.

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Section: The Bronchiectasis Bacteriome In the Asia-pacific Regionmentioning

confidence: 92%

Section: Bronchiectasis In the Asia-pacific Regionmentioning

confidence: 99%

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

et al. 2018

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“…Clinical symptoms of BE include cough, sputum, and hemoptysis. Progression of BE is related to neutrophilic inflammation induced by bacterial infection, and 84% of BE patients have sputum cultures positive for pathogens (13). Common etiologies of BE have been reported to be idiopathic, sinobronchial syndrome, and non-tuberculous mycobacteriosis in Japan, in contrast to immune dysfunction in the US (14).…”

Section: Original Article Characteristics and Prognosis Of Microscopimentioning

confidence: 99%

Characteristics and prognosis of microscopic polyangiitis with bronchiectasis

et al. 2017

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Background: Major pulmonary manifestations associated with microscopic polyangiitis (MPA) include diffuse alveolar hemorrhage (DAH) and interstitial pneumonia (IP).We previously showed bronchiectasis (BE) was one of the pulmonary complications of MPA. However, clinical features of BE patients with MPA are not fully understood. We investigated the characteristics and prognosis of BE patients with MPA.Methods: Forty-five MPA patients were retrospectively studied. The patients were divided into two groups:patients with BE and those without BE.Results: Thirty-one of 45 patients (69%) had pulmonary involvement including IP (23/45, 51%), BE (7/45, 16%), and DAH (5/45, 11%). There were no differences between the patients with BE versus those without with regard to clinical characteristics and initial treatments. However, the prognosis for patients with BE was better than those without BE during the first year after diagnosis, but it was worse between 1 and 5 years, which was statistically significant. Two BE patients died between 1 and 5 years as a result of pneumonia.Conclusions: BE as a complication of MPA might be related to lower mortality in the acute phase and higher mortality in the chronic phase compared to other pulmonary manifestations. More attention to pulmonary infection is needed for patients with BE during the chronic phase.

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“…Previous chest CT scans were reviewed retrospectively and evaluated. In order to evaluate structural lung abnormalities related to P. aeruginosa infection, the following radiological patterns were sought: bronchiolitis (small nodules <5 mm in diameter, arranged in a centrilobular fashion), bronchiectasis (1.5 times as wide as a nearby vessel and a lack of bronchial tapering on sequential slices), traction bronchiectasis, and emphysema (Poletti et al, 2006;Yamazaki et al, 2016;Naito et al, 2017;Kadowaki et al, 2015).…”

Section: Radiological Examinationmentioning

confidence: 99%

Anti-PcrV titers in non-cystic fibrosis patients with Pseudomonas aeruginosa respiratory tract infection

Nagaoka

Yamashita

Kimura

et al. 2019

International Journal of Infectious Diseases

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The epidemiology and role of the anti-PcrV titer in non-cystic fibrosis patients with Pseudomonas aeruginosa airway tract infections is not fully understood. This study was performed to compare the anti-PcrV titers of patients with and without P. aeruginosa respiratory tract infections. Methods: This prospective cohort study was conducted at Hokkaido University Hospital in Japan. Participants had blood and sputum specimens collected on admission. They were divided into two groups based on their sputum culture results. Those with a P. aeruginosa infection were assigned to the P. aeruginosa (PA) group and those without a P. aeruginosa infection were assigned to the non-PA group. Serum anti-PcrV titers were measured using a validated ELISA. Results: Of the 44 participants, 15 were assigned to the PA group and 29 were assigned to the non-PA group. In the PA group, 10/15 participants (66.7%) had an anti-PcrV titer >1000 ng/ml compared to 3/29 participants (10.3%) in the non-PA group (p < 0.001). In the PA group, two of the five participants with an anti-PcrV titer <1000 ng/ml died of recurrent P. aeruginosa pneumonia; the other three participants did not develop pneumonia. Conclusion: The anti-PcrV titers in participants with P. aeruginosa infection varied considerably. Patients with low anti-PcrV titers and refractory P. aeruginosa infections need to be monitored closely.

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An analysis of etiology, causal pathogens, imaging patterns, and treatment of Japanese patients with bronchiectasis

Cited by 30 publications

References 24 publications

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Characteristics and prognosis of microscopic polyangiitis with bronchiectasis

Anti-PcrV titers in non-cystic fibrosis patients with Pseudomonas aeruginosa respiratory tract infection

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