An Analysis of HLA-A, -B, and -DRB1 Allele and Haplotype Frequencies of 21,918 Residents Living in Liaoning, China

Abstract

HLA-A, -B and -DRB1 allele frequencies and their haplotype frequencies in 21,918 Chinese residents living in Liaoning Province, who were registered as volunteer donors of China Marrow Donor Registry, were investigated. They are composed of 93.37% Han Chinese, 5.1% Manchus, 0.57% Mongols, 0.46% Hui persons, 0.29% Koreans and 0.14% Xibe ethnic group. In total eighteen different HLA-A alleles, forty-eight different HLA-B alleles and fourteen different HLA-DRB1 alleles have been identified. Their frequencies are in agreement with the Hardy-Weinberg equilibrium. For Han Chinese in Liaoning, 1,534 different HLA-A-B-DRB1 haplotypes were identified, with a frequency of higher than 0.01%. A*30-B*13-DRB1*07, A*02-B*46-DRB1*09 and A*02-B*13-DRB1*12 are the most frequent haplotypes among Liaoning Han. While Liaoning Han, Liaoning Manchu, Liaoning Mongol, Liaoning Hui and Liaoning Korean share the northern Han characteristic haplotypes, all minority ethnic groups with the exception of Liaoning Manchu have developed their own unique HLA profiles. This dataset characterizes the HLA allele and haplotype frequencies in the Liaoning area and suggests that it is different from those in other parts of China and ethnic groups, which implicates transplant donor searching strategies and studies on population genetics.

HLA‐A, HLA‐B, HLA‐DRB1 allele and haplotype frequencies of 14 529 Chinese Han bone marrow donors living in Dalian, China

“…Pairwise F ST values calculated by arlequin software among 13 different populations. The genetic distance is indicated by the depth of the colour in the crossing area of pairwise populations DL: Dalian; LN: Liaoning (Li et al ., ); YW: Yantai‐Weihai (Zhang et al ., ); SH: Shanghai (Du et al ., ); KOR: Korea (Whang et al ., ); NEA: North‐east Asia; SEA: South‐east Asia; SWA: South‐west Asia; AUS: Australia; EUR: Europe; NA: North America; SSA: Sub‐Saharan Africa; BRA: Brazil (Macêdo et al ., ). NEA, SEA, SWA, AUS, EUR, NA and SSA data were obtained from http://www.ncbi.nlm.nih.gov/projects/gv/mhc/main.fcgi?cmd=init.…”

In silicodesign of a DNA-based HIV-1 multi-epitope vaccine for Chinese populations

“…1A). 31,32 In this paper, we report the optimized design of a multi-epitope vaccine that takes into account all of these issues. Several elements were considered for our multiple-epitope vaccine design: epitope selection, epitope location, and linkers between epitopes.…”

Allelic and haplotype diversity of HLA‐A, HLA‐B and HLA‐DRB1 gene at high resolution in the Nanning Han population

“…In our study, the results showed that HLA‐A*33:03~B*58:01~DRB1*03:01 is the most common haplotype in the Nanning Han population, which is similar to the southern Chinese population and southern East Asia populations (Ding et al, ; He et al, ; Hoa et al, ; Lai et al, ; Shi et al, ). However, HLA‐A*30:01~B*13:02~DRB1*07:01 is the most frequent haplotype in the north Han populations but less common in the Nanning Han population (Li et al, ; Shao et al, ). In fact, it just reflects the general north–south genetic differentiation observed in many studies focusing on HLA alleles (Di & Sanchez‐Mazas, ) or other genetic markers, especially for markers on Y chromosomes and mitochondrial DNA (mtDNA; Zhang, Su, Zhang, & Jin, ).…”

“…The human MHC is human leucocyte antigen (HLA) system. HLA is located on the chromosome 6 in the 6 P 21.31 region and is the most polymorphic genes in the human genome (Li et al, ). To date, January 2018, total of 17,695 HLA alleles have been identified according to the IMGT/HLA Database (release Version 3.31.0).…”