An analysis of interdigitated electrode geometry for dielectrophoretic particle transport in micro-fluidics

Crews, Niel; Darabi, J.; Voglewede, Philip A.; Guo, Fangfang; Bayoumi, Abdel

doi:10.1016/j.snb.2007.02.047

Cited by 58 publications

(38 citation statements)

References 11 publications

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“…Wang et al (1996) compared the analytical solution from Green's Theorem based method with charge density method, whereas Green et al (2002) compared the analytical solution from Fourier series method with numerical solution solved by finite element method. Clague & Wheeler (2001), and Crews et al (2001) studied the effect of electrode dimensions, channel height and applied voltage on gradient of squared electric field. Molla & Bhattacharjee (2005a;b) compared the Green's theorem based analytical and finite element based numerical solutions as well as studied the effect of applied voltages and frequencies on DEP force.…”

Section: Solution Methodologymentioning

confidence: 99%

“…(20) with surface potential boundary conditions on electrode plane. Assuming the linear variation of surface potential at gap between the electrodes (Chang et al, 2003;Clague & Wheeler, 2001;Crews et al, 2001;Green et al, 2002;Molla & Bhattacharjee, 2005a;b;Morgan et al, 2001;Wang et al, 1996), the surface potential boundary conditions on electrodes and gap between electrodes are given as…”

Section: Solution Methodologymentioning

confidence: 99%

See 1 more Smart Citation

Dielectrophoresis for Manipulation of Bioparticles

Gunda¹,

Mitra²

2011

Biomedical Engineering - Frontiers and Challenges

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Section: Solution Methodologymentioning

confidence: 99%

Section: Solution Methodologymentioning

confidence: 99%

Dielectrophoresis for Manipulation of Bioparticles

Gunda¹,

Mitra²

2011

Biomedical Engineering - Frontiers and Challenges

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“…65 The closed form solutions ͑CFSs͒ are also developed for electric field and DEP forces by Morgan et al 65 and Chang et al 66 Wang et al 60 compared the analytical solution from Green's theorem based method with charge density method, whereas Green et al 67 compared the analytical solution from the Fourier series method with numerical solution solved by finite element method. Clague and Wheeler 61 and Crew et al 68 studied the effect of electrode dimensions, channel height, and applied voltage on gradient of electric field square. Molla and Bhattacharjee 62,63 compared Green's theorem based analytical and finite element based numerical solutions, as well as studied the effect of applied voltages and frequencies on DEP force.…”

Section: Solution Methodologymentioning

confidence: 99%

Modeling of dielectrophoretic transport of myoglobin molecules in microchannels

Gunda

Mitra

2010

Biomicrofluidics

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Myoglobin is one of the premature identifying cardiac markers, whose concentration increases from 90 pg/ml or less to over 250 ng/ml in the blood serum of human beings after minor heart attack. Separation, detection, and quantification of myoglobin play a vital role in revealing the cardiac arrest in advance, which is the challenging part of ongoing research. In the present work, one of the electrokinetic approaches, i.e., dielectrophoresis ͑DEP͒, is chosen to separate the myoglobin. A mathematical model is developed for simulating dielectrophoretic behavior of a myoglobin molecule in a microchannel to provide a theoretical basis for the above application. This model is based on the introduction of a dielectrophoretic force and a dielectric myoglobin model. A dielectric myoglobin model is developed by approximating the shape of the myoglobin molecule as sphere, oblate, and prolate spheroids. A generalized theoretical expression for the dielectrophoretic force acting on respective shapes of the molecule is derived. The microchannel considered for analysis has an array of parallel rectangular electrodes at the bottom surface. The potential and electric field distributions are calculated using Green's theorem method and finite element method. These results also compared to the Fourier series method, closed form solutions by Morgan et al. ͓J. Phys. D: Appl. Phys. 34, 1553 ͑2001͔͒ and Chang et al. ͓J. Phys. D: Appl. Phys. 36, 3073 ͑2003͔͒. It is observed that both Green's theorem based analytical solution and finite element based numerical solution for proposed model are closely matched for electric field and square electric field gradients. The crossover frequency is obtained as 40 MHz for given properties of myoglobin and for all approximated shapes of myoglobin molecule. The effect of conductivity of medium and myoglobin on the crossover frequency is also demonstrated. Further, the effect of hydration layer on the crossover frequency of myoglobin molecules is also presented. Both positive and negative DEP effects on myoglobin molecules are obtained by switching the frequency of applied electric field. The effect of different shapes of myoglobin on DEP force is studied and no significant effect on DEP force is observed. Finally, repulsion of myoglobin molecules from the electrode plane at 1 KHz frequency and 10 V applied voltage is observed. These results provide the ability of applying DEP force for manipulating nanosized biomolecules such as myoglobin.

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“…13) where Ф is the electric potential and E denotes the electric field strength. the boundary conditions were selected as neumann and Dirichlet boundary condition according to their different functions in DeP operation (2). the electrode was trapezoid with top width 20 mm, bottom width 40 mm, and length 100 mm.…”

Section: Numerical Simulationmentioning

confidence: 99%

“…the traveling-wave dielectrophoresis devices were developed and used for transfer of polystyrene (3), blood cells (17), and whole blood (18) etc. At the same time, the transporting mechanism of particles in traveling-wave DeP and the effects of interdigitated electrode geometry on DeP transport were investigated to reveal the relation of particles motion and the applied signal (2,12). Furthermore, the moving dielectrophorsis has recently been introduced to transport cells in microfluid system, which allows cells to be fractionated as in conventional DeP but transported as in twDeP operation (14).…”

Section: Introductionmentioning

confidence: 99%