An analysis of plasma reveals proteins in the acute phase response pathway to be candidate diagnostic biomarkers for depression

Wang, Qi; Yu, Chunyue; Shi, Shanshan; Su, Xiaojie; Zhang, Jian; Ding, Yongqing; Sun, Yanan; Liu, Min; Li, Chunquan; Zhao, Xiwu; Jiang, Wen-An; Wei, Taiming

doi:10.1016/j.psychres.2018.11.069

Cited by 16 publications

(10 citation statements)

References 49 publications

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“…LXR/RXR activation, which is involved in the regulation of the inflammatory response and lipid metabolism. Additionally, the acute phase response signaling, often presented in depressed patients (Wang et al, 2018), was also shown in the present LPS depression model. The most important is Ephrin receptor signaling, as the fourth top-ranked statistically canonical pathways in the bi-omics, which regulates neuroinflammation and nervous system development through mediating glutamatergic neurotransmission, and neuroplasticity (Dines and Lamprecht, 2016;Wan et al, 2018).…”

Section: Integrated Analysis Of Proteomics and Metabolomicssupporting

confidence: 65%

Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Wei

et al. 2019

Front. Neurosci.

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Section: Integrated Analysis Of Proteomics and Metabolomicssupporting

confidence: 65%

Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Wei

et al. 2019

Front. Neurosci.

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“…These genes are highly related to depression. Consistently, Serpind1 is considered a candidate gene for depression (Wang et al, 2019). We noticed that Wfs1 is the overlapping gene of the first ten differential genes.…”

Section: Discussionmentioning

confidence: 60%

Wfs1 and Related Molecules as Key Candidate Genes in the Hippocampus of Depression

et al. 2021

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BackgroundDepression is a prevalent mental disorder, which is difficult to diagnose and treat due to its unclear pathogenic mechanisms. The discovery of novel and effective therapeutic targets for depression is urgently needed. The hippocampus is a crucial region involved in depression and has been a therapeutic target for many antidepressants. Thus, it is beneficial for comprehensive research to be carried out on the molecular mechanisms of the hippocampus involved in the pathogenesis of depression. This study aims to investigate the differentially expressed genes (DEG) in the hippocampus in a chronic unpredictable mild stress (CUMS) mouse model.MethodThe study obtained GSE84183 from the GEO database. The R language screened the differential expression genes (DEG) in the hippocampus tissue of depressed mice, and the enrichment pathways of DEGs were analyzed. A protein-protein interaction (PPI) network was constructed in the STRING database and visualized in Cytoscape software. MicroRNAs for these DEGs were obtained from TarBase and mortar base databases, and transcription factors (TF) related to DEG were predicted from the ENCODE database. Both networks used the visual analysis platform NetworkAnalyst. Finally, the microRNA-TF network was integrated based on the above two networks and imported into Cytoscape for further analysis.ResultsThis study screened 325 differentially expressed genes, containing 42 downregulated genes and 283 upregulated genes. Most of these genes are enriched in the cell cycle and the chemokine signaling pathway. Meanwhile, Wfs1, one of the top ten DEGs, was identified as the key regulator of the cell cycle and the participator in the highest number of modules screened out in PPI networks. Wfs1-related molecules, including UBTF, mmu-mir-17-5p, and mmu-mir-7b-5p, were therefore screened out. Furthermore, we confirmed the downregulation of Wfs1 and upregulation of UBTF/mmu-mir-17-5p/mmu-mir-7b-5p in the hippocampus of the CUMS mouse model. Our data indicate that Wfs1 and related molecules were predicted to be associated with the pathological process of depression. This research provided potential new molecular targets of stress-induced depression.

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“…There are also reports suggesting that affective disorders, including depression, are characterized by disturbances of the oxidant/antioxidant balance, that in consequence lead to damage of cellular macromolecules. [12][13][14][15][16][17] Reactive oxygen and nitrogen species can cause changes in cell membranes, receptor and enzymes functions, as well as activity of genes, and these imbalances can be influenced by antidepressant treatments. 14,18,19 Among the signs of antioxidant defects, increased levels of 8-F2-isoprostane (8-iso-PGF2α), malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine have been found in depressed patients and are also believed to be markers of the effectiveness of an antidepressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Wigner

Synowiec

Czarny

et al. 2020

J Cellular Molecular Medi

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An analysis of plasma reveals proteins in the acute phase response pathway to be candidate diagnostic biomarkers for depression

Cited by 16 publications

References 49 publications

Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Wfs1 and Related Molecules as Key Candidate Genes in the Hippocampus of Depression

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

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