Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Wu, Yu; Wei, Zhenhong; Li, Yonghong; Wei, Chaojun; Li, Yuanting; Cheng, Pengfei; Xu, Hui; Li, Zhenhao; Guo, Rui; Qi, Xiaoming; Jia, Jing; Jia, Yanjuan; Wang, Wanxia; Gao, Xiaoling

doi:10.3389/fnins.2019.01359

Cited by 21 publications

(12 citation statements)

References 64 publications

(128 reference statements)

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“…The levels of VMA and L-DOPA were reported to be related to depressive behaviors, which is consistent with the results of all the included studies that a higher level of tyrosine was identified in the PSD group than the non-depressed group. In contrast, patients with depression had reduced metabolites level of DA in the CSF ( 86 ) and in the hypothalamus of depression model mouse ( 87 ), results of which were consistent with the monoamine hypothesis. In summary, the different levels of metabolites might present the switch between depression and remission.…”

Section: Discussionsupporting

confidence: 69%

Does urinary metabolite signature act as a biomarker of post-stroke depression?

et al. 2022

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BackgroundIt is difficult to conduct the precise diagnosis of post-stroke depression (PSD) in clinical practice due to the complex psychopathology of depressive disorder. Several studies showed that gas chromatography–mass spectrometry (GC-MS)-identified urinary metabolite biomarkers could significantly discriminate PSD from stroke survivors.MethodsA systematic review was performed for the keywords of “urinary metabolite” and “PSD” using Medline, Cochrane Library, Embase, Web of Science, PsycINFO, Wanfang, CNKI, CBM, and VIP database from inception to 31 March 2022.ResultsFour related studies were included in the review. Differential urinary metabolites including lactic acid, palmitic acid, azelaic acid, and tyrosine were identified in all the included studies. As a significant deviation in the metabolite biomarker panel, glyceric acid, azelaic acid, phenylalanine, palmitic acid, pseudouridine, and tyrosine were found in at least 2 included studies, which indicated good potential for the differentiation of PSD.ConclusionThe systematic review provided evidence that differential urinary metabolites analyzed by the GC-MS-based approach might be used as a biomarker for the diagnosis and prognosis of PSD.

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Section: Discussionsupporting

confidence: 69%

Does urinary metabolite signature act as a biomarker of post-stroke depression?

et al. 2022

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“…IPA revealed that the top significantly changed canonical pathways are related to FXR/RXR activation, LXR/RXR activation, and LPS/IL-1-mediated inhibition of RXR function, and this was consistent with that of the previous reports in the literature. We found that FXR/RXR and LXR/RXR are involved in many diseases, such as hypothalamic dysfunction [ 18 ], germ cell development [ 19 ], adipose stem cells (ASCs) [ 20 ], colorectal cancer (CRC) [ 21 ], and major depressive disorder [ 22 ]. A study has found that the stimulation of glutamine to ASCT2 expression partly involves the binding of FXR/RXR to the ASCT2 promoter [ 23 ], which might be the key to the proliferation and survival of HepG2 cells.…”

Section: Discussionmentioning

confidence: 99%

Screening and Functional Prediction of Key Candidate Genes in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Chen

Ling

et al. 2020

BioMed Research International

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Background. The molecular mechanism by which hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) is still unknown. The genomic expression profile and bioinformatics methods were used to investigate the potential pathogenesis and therapeutic targets for HBV-associated HCC (HBV-HCC). Methods. The microarray dataset GSE55092 was downloaded from the Gene Expression Omnibus (GEO) database. The data was analyzed by the bioinformatics software to find differentially expressed genes (DEGs). Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, ingenuity pathway analysis (IPA), and protein-protein interaction (PPI) network analysis were then performed on DEGs. The hub genes were identified using Centiscape2.2 and Molecular Complex Detection (MCODE) in the Cytoscape software (Cytoscape_v3.7.2). The survival data of these hub genes was downloaded from the Gene Expression Profiling Interactive Analysis (GEPIA). Results. A total of 2264 mRNA transcripts were differentially expressed, including 764 upregulated and 1500 downregulated in tumor tissues. GO analysis revealed that these DEGs were related to the small-molecule metabolic process, xenobiotic metabolic process, and cellular nitrogen compound metabolic process. KEGG pathway analysis revealed that metabolic pathways, complement and coagulation cascades, and chemical carcinogenesis were involved. Diseases and biofunctions showed that DEGs were mainly associated with the following diseases or biological function abnormalities: cancer, organismal injury and abnormalities, gastrointestinal disease, and hepatic system disease. The top 10 upstream regulators were predicted to be activated or inhibited by Z-score and identified 25 networks. The 10 genes with the highest degree of connectivity were defined as the hub genes. Cox regression revealed that all the 10 genes (CDC20, BUB1B, KIF11, TTK, EZH2, ZWINT, NDC80, TPX2, MELK, and KIF20A) were related to the overall survival. Conclusion. Our study provided a registry of genes that play important roles in regulating the development of HBV-HCC, assisting us in understanding the molecular mechanisms that underlie the carcinogenesis and progression of HCC.

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“…Due to their complex and wide influence on other genes, Eph receptors are capable of influencing a variety of biological outcomes 62 – 64 . Dysregulated Eph receptor signaling has been implicated in abnormal neural development and altered synaptic transmission 65 , 66 . Gene networks of RhoA signaling, Rac signaling, and Signaling by Rho Family GTPases also play important roles in neuronal functioning, and were upregulated in the EPN_non-enriched group and downregulated in the EPN_enriched group.…”

Section: Discussionmentioning

confidence: 99%

Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment

Singh

Kim

et al. 2022

Sci Rep

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Early life lead (Pb) exposure is detrimental to neurobehavioral development. The quality of the environment can modify negative influences from Pb exposure, impacting the developmental trajectory following Pb exposure. Little is known about the molecular underpinnings in the brain of the interaction between Pb and the quality of the environment. We examined relationships between early life Pb exposure and living in an enriched versus a non-enriched postnatal environment on genome-wide transcription profiles in hippocampus CA1. RNA-seq identified differences in the transcriptome of enriched vs. non-enriched Pb-exposed animals. Most of the gene expression changes associated with Pb exposure were reversed by enrichment. This was also true for changes in upstream regulators, splicing events and long noncoding RNAs. Non-enriched rats also had memory impairments; enriched rats had no deficits. The results demonstrate that an enriched environment has a profound impact on behavior and the Pb-modified CA1 transcriptome. These findings show the potential for interactions between Pb exposure and the environment to result in significant transcriptional changes in the brain and, to the extent that this may occur in Pb-exposed children, could influence neuropsychological/educational outcomes, underscoring the importance for early intervention and environmental enrichment for Pb-exposed children.

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Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Cited by 21 publications

References 64 publications

Does urinary metabolite signature act as a biomarker of post-stroke depression?

Does urinary metabolite signature act as a biomarker of post-stroke depression?

Screening and Functional Prediction of Key Candidate Genes in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment

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