An Analysis of the Antitumor Effects of Corynebacterium parvum

Castro, J. E.; Sadler, T E

doi:10.1007/978-1-4613-4428-5_28

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Since Halpern et al [21] reported that Corynebacterium parvum stimulated the carbonclearing activity in mice, it has been known that anaerobic coryneforms including C. parvum, Corynebacterium acnes and Corynebacterium granulosum showed several biological activities, such as antitumor action [10,13,16,18,20,26,35], adjuvant action in immune response [23,29,33,34,38,40], resistance to bacterial infection [2,11,19] and enhancement of histamine sensitivity in animals [1]. Anaerobic coryneforms inhabit the skin, oral cavities, intestines or vaginas of humans, and some of them may be isolated from comedones, pustules and acne vulgaris lesions.…”

mentioning

confidence: 42%

Anaerobic Coryneforms Isolated from Human Bone Marrow and Skin

Saino¹,

Eda²,

Nagoya³

et al. 1976

Japanese Journal of Microbiology

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Eighteen isolates of anaerobic coryneforms from human bone marrow and skin and four type strains of Propionibacterium were studied chemically, biochemically and antigenically. All of the isolates were identified as Propionibacterium acnes; of the 18 isolates, 16 belonged to serotype I and two to serotype II. By means of gas liquid chromatography and mass spectral analysis, a large amount of iso-type fatty acids, such as iso-pentadecanoic and iso-heptadecanoic acids were detected in whole cells of isolates and type strains. Antitumor and adjuvant effects of the isolates and type strains were found to differ considerably among the strains. One of the isolates, P. acnes C-7, which showed potent biological activities was fractionated by hot phenol-water extraction.The resulting insoluble middle layer was found the most effective in tumor protection, adjuvant action in immune response and phagocytic activity in mice.

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mentioning

confidence: 42%

Anaerobic Coryneforms Isolated from Human Bone Marrow and Skin

Saino¹,

Eda²,

Nagoya³

et al. 1976

Japanese Journal of Microbiology

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“…It is well known that the cells of anaerobic Corynebacterium granulosum and Corynebacterium acnes, have several biological activities, stimulation of reticuloendothelial systems and resistance to infection [12], adjuvant activity in immune response [14-16, 22-24, 30, 33, 34] and antitumor activity [8,18,[25][26][27]. Recently, it was reported that the chemical analysis of the cell wall components gave useful informations on the taxonomy of microorganisms [3,6,9,17].…”

supporting

confidence: 45%

Chemical and Immunological Studies on the Cell Walls of Propionibacterium acnes Strain C7 and Corynebacterium parvum ATCC 11829

Azuma

Sugimura

Taniyama

et al. 1975

Japanese Journal of Microbiology

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The chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, Propionibacterium acnes C7 and Corynebacterium parvum ATCC 11829, were partially investigated. The cell walls prepared from P. acnes C7 and C. parvum ATCC 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, a, ε‐diaminopimelic acid, glycine, muramic acid and glucosamine. As the fatty acid constituents of the cell wall of P. acnes C7, iso‐pentadecanoic acid and iso‐heptadecanoic acid were detected as major components. Both cell walls prepared from P. acnes C7 and C. parvum ATCC 11829 showed potent adjuvant activity on the formation of circulating antibody and development of delayed type hypersensitivity in vivo and on the primary immune response to sheep erythrocytes in vitro, however, could not augment helper function of carrier‐primed T cells and on the development of cell‐mediated cytotoxicity to mastocytoma P815‐X2 cells in C57BL/6J mice. It is also shown that the cell walls of P. acnes C7 and C. parvum ATCC 11829 act on mouse spleen cells as mitogen.

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“…16,24,33,35 Levamisole is an immunotropic agent which primarily potentiates the immune responses in immuno-deficient host^. ',^,'^,^^ It is generally accepted that adoptive transfer of specific transplantation resistance can be achieved by transfer of syngeneic sensitized cells.…”

Section: Figmentioning

confidence: 46%

“…For technical reasons, plasmapheresis and extracorporeal immunoabsorption procedures can optimally be performed in larger animals or man.7,8 Therefore, unblocking serotherapy was used in this experiment to counteract serum blocking activity in viuo along with splenectomy which has been shown to decrease temporarily serum blocking activity in tumor host.13 It is recognized that effects obtained by unblocking serotherapy might be due to mechanisms other than its unblocking effect, such as complement dependent cytotoxic activity13 or arming effect.s Covynebacterium parvum has been shown to possess antitumor e f f e~t~.~~j~~,~~,~~,~~ The mechanisms of its action in viuo are not understood, but published reports indicate that the administration of C. par-vum to tumor host increases the cytotoxicity of macrophages. 16,24,33,35 Levamisole is an immunotropic agent which primarily potentiates the immune responses in immuno-deficient host^. ',^,'^,^^ It is generally accepted that adoptive transfer of specific transplantation resistance can be achieved by transfer of syngeneic sensitized cells.…”

Section: Discussionmentioning

confidence: 99%

Multimodal immunotherapy of primary gastrointestinal tumors in rats. 1 Histologic correlation

Bansal

Mobini

Bansal

1978

Cancer

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The effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Multimodal immune manipulation consisted of combinations of splenectomy, C. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. Such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. Ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with normal rabbit serum died of progressive tumor growth. None of the rats treated with combinations of splenectomy, unblocking serum, unblocked lymphoid cells, C. parvum and levamisole succumbed to progressive tumor growth during the observation period. The histologic evidence of tumor destruction was obtained in 18 of 22 tumors in rats of groups receiving multimodal immunotherapy.

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An Analysis of the Antitumor Effects of Corynebacterium parvum

Cited by 8 publications

References 9 publications

Anaerobic Coryneforms Isolated from Human Bone Marrow and Skin

Anaerobic Coryneforms Isolated from Human Bone Marrow and Skin

Chemical and Immunological Studies on the Cell Walls of Propionibacterium acnes Strain C7 and Corynebacterium parvum ATCC 11829

Multimodal immunotherapy of primary gastrointestinal tumors in rats. 1 Histologic correlation

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